Systematic identification of tRNA genes in Drosophila melanogaster

Transfer RNAs (tRNAs) are ubiquitous adapter molecules that link specific codons in messenger RNA (mRNA) with their corresponding amino acids during protein synthesis. The tRNA genes of Drosophila have been investigated for over half a century but have lacked systematic identification and nomenclatu...

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Detalles Bibliográficos
Autores principales: Marygold, Steven J, Chan, Patricia P, Lowe, Todd M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2022
Materias:
Data Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249942/
https://www.ncbi.nlm.nih.gov/pubmed/35789696
http://dx.doi.org/10.17912/micropub.biology.000560
Descripción
Sumario:Transfer RNAs (tRNAs) are ubiquitous adapter molecules that link specific codons in messenger RNA (mRNA) with their corresponding amino acids during protein synthesis. The tRNA genes of Drosophila have been investigated for over half a century but have lacked systematic identification and nomenclature. Here, we review and integrate data within FlyBase and the Genomic tRNA Database (GtRNAdb) to identify the full complement of tRNA genes in the D. melanogaster nuclear and mitochondrial genomes. We apply a logical and informative nomenclature to all tRNA genes, and provide an overview of their characteristics and genomic features.

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