Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine al...

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Detalles Bibliográficos
Autores principales: Yu, Guang-Xing, Wu, Jing, Shi, Bao-Bao, Bao, Mei-Fen, Cai, Xiang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249953/
https://www.ncbi.nlm.nih.gov/pubmed/35778536
http://dx.doi.org/10.1007/s13659-022-00344-1
Descripción
Sumario:Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00344-1.

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