Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri

Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine al...

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Autores principales: Yu, Guang-Xing, Wu, Jing, Shi, Bao-Bao, Bao, Mei-Fen, Cai, Xiang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249953/
https://www.ncbi.nlm.nih.gov/pubmed/35778536
http://dx.doi.org/10.1007/s13659-022-00344-1
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author Yu, Guang-Xing
Wu, Jing
Shi, Bao-Bao
Bao, Mei-Fen
Cai, Xiang-Hai
author_facet Yu, Guang-Xing
Wu, Jing
Shi, Bao-Bao
Bao, Mei-Fen
Cai, Xiang-Hai
author_sort Yu, Guang-Xing
collection PubMed
description Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00344-1.
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spelling pubmed-92499532022-07-03 Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri Yu, Guang-Xing Wu, Jing Shi, Bao-Bao Bao, Mei-Fen Cai, Xiang-Hai Nat Prod Bioprospect Original Article Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones. The new structures were elucidated based on spectroscopic data including 1D and 2D NMR, MS and calculated ECD spectra. Among them, (+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids. The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-022-00344-1. Springer Nature Singapore 2022-07-01 /pmc/articles/PMC9249953/ /pubmed/35778536 http://dx.doi.org/10.1007/s13659-022-00344-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Yu, Guang-Xing
Wu, Jing
Shi, Bao-Bao
Bao, Mei-Fen
Cai, Xiang-Hai
Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title_full Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title_fullStr Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title_full_unstemmed Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title_short Enantiomeric Cephalotaxus alkaloids from seeds of Cephalotaxus oliveri
title_sort enantiomeric cephalotaxus alkaloids from seeds of cephalotaxus oliveri
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249953/
https://www.ncbi.nlm.nih.gov/pubmed/35778536
http://dx.doi.org/10.1007/s13659-022-00344-1
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