Predicting the functional effects of voltage-gated potassium channel missense variants with multi-task learning

BACKGROUND: Variants in genes encoding voltage-gated potassium channels are associated with a broad spectrum of neurological diseases including epilepsy, ataxia, and intellectual disability. Knowledge of the resulting functional changes, characterized as overall ion channel gain- or loss-of-function...

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Detalles Bibliográficos
Autores principales: Boßelmann, Christian Malte, Hedrich, Ulrike B.S., Müller, Peter, Sonnenberg, Lukas, Parthasarathy, Shridhar, Helbig, Ingo, Lerche, Holger, Pfeifer, Nico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250003/
https://www.ncbi.nlm.nih.gov/pubmed/35759918
http://dx.doi.org/10.1016/j.ebiom.2022.104115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250003/
https://www.ncbi.nlm.nih.gov/pubmed/35759918
http://dx.doi.org/10.1016/j.ebiom.2022.104115

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