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A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing

Full-thickness wounds, lacking the epidermis and entire dermis and extending into subcutaneous fat, represent a common treatment challenge. Due to the loss of adnexal structures as a source of keratinocytes, full-thickness wounds healing can only be achieved by re-epithelialization from the wound ed...

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Autores principales: Hu, Honghua, Zhai, Xinrang, Li, Wenyue, Ji, Shunxian, Dong, Wei, Chen, Weiyu, Wei, Wei, Lu, Zhongfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250026/
https://www.ncbi.nlm.nih.gov/pubmed/35789848
http://dx.doi.org/10.1016/j.isci.2022.104619
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author Hu, Honghua
Zhai, Xinrang
Li, Wenyue
Ji, Shunxian
Dong, Wei
Chen, Weiyu
Wei, Wei
Lu, Zhongfa
author_facet Hu, Honghua
Zhai, Xinrang
Li, Wenyue
Ji, Shunxian
Dong, Wei
Chen, Weiyu
Wei, Wei
Lu, Zhongfa
author_sort Hu, Honghua
collection PubMed
description Full-thickness wounds, lacking the epidermis and entire dermis and extending into subcutaneous fat, represent a common treatment challenge. Due to the loss of adnexal structures as a source of keratinocytes, full-thickness wounds healing can only be achieved by re-epithelialization from the wound edge and contraction. Here, we developed a hydrogel composed of chitosan methacrylate (CSMA) and o-nitrosobenzaldehyde-modified gelatin (GelNB) for promoting full-thickness wound healing. The CSMA/GelNB (CM/GN) hydrogels exhibited superior mechanical and adhesive properties than that of pure CSMA hydrogel. In vivo experiments confirmed that CM/GN could promote wound healing by generating more hair follicles and mutual blood vessels, high fibroblasts density, and thicker granulation tissue thickness. In addition, reduced secretions of tumor necrosis factor-α (TNF-α) and enhanced secretions of vascular endothelial growth factor (VEGF) could be observed in regenerated tissues after CM/GN treatment. These results suggested that CM/GN hydrogels could be promising candidates to promote wound healing.
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spelling pubmed-92500262022-07-03 A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing Hu, Honghua Zhai, Xinrang Li, Wenyue Ji, Shunxian Dong, Wei Chen, Weiyu Wei, Wei Lu, Zhongfa iScience Article Full-thickness wounds, lacking the epidermis and entire dermis and extending into subcutaneous fat, represent a common treatment challenge. Due to the loss of adnexal structures as a source of keratinocytes, full-thickness wounds healing can only be achieved by re-epithelialization from the wound edge and contraction. Here, we developed a hydrogel composed of chitosan methacrylate (CSMA) and o-nitrosobenzaldehyde-modified gelatin (GelNB) for promoting full-thickness wound healing. The CSMA/GelNB (CM/GN) hydrogels exhibited superior mechanical and adhesive properties than that of pure CSMA hydrogel. In vivo experiments confirmed that CM/GN could promote wound healing by generating more hair follicles and mutual blood vessels, high fibroblasts density, and thicker granulation tissue thickness. In addition, reduced secretions of tumor necrosis factor-α (TNF-α) and enhanced secretions of vascular endothelial growth factor (VEGF) could be observed in regenerated tissues after CM/GN treatment. These results suggested that CM/GN hydrogels could be promising candidates to promote wound healing. Elsevier 2022-06-16 /pmc/articles/PMC9250026/ /pubmed/35789848 http://dx.doi.org/10.1016/j.isci.2022.104619 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Honghua
Zhai, Xinrang
Li, Wenyue
Ji, Shunxian
Dong, Wei
Chen, Weiyu
Wei, Wei
Lu, Zhongfa
A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title_full A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title_fullStr A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title_full_unstemmed A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title_short A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
title_sort photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250026/
https://www.ncbi.nlm.nih.gov/pubmed/35789848
http://dx.doi.org/10.1016/j.isci.2022.104619
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