Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress

While schizophrenia pathogenesis involves both genetic and environmental factors, their specific combinations remain ill-defined. Here we show that deficiency in promoter VI-driven BDNF expression, combined with early-life adversity, results in schizophrenia-like endo-phenotypes. Promoter VI mutant...

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Detalles Bibliográficos
Autores principales: Chen, Yanhui, Li, Shangjin, Zhang, Tianyi, Yang, Feng, Lu, Bai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250029/
https://www.ncbi.nlm.nih.gov/pubmed/35789832
http://dx.doi.org/10.1016/j.isci.2022.104609

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