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Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice

BACKGROUND: Dietary nucleotides [inclusion adenosine 5’-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. He...

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Autores principales: Wu, Zifang, Rao, Sujuan, Li, Jiaying, Ding, Ning, Chen, Jianzhao, Feng, Li, Ma, Shuo, Hu, Chengjun, Dai, Haonan, Wen, Lijun, Jiang, Qingyan, Deng, Jinping, Deng, Ming, Tan, Chengquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Academia 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250134/
https://www.ncbi.nlm.nih.gov/pubmed/35844957
http://dx.doi.org/10.29219/fnr.v66.7680
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author Wu, Zifang
Rao, Sujuan
Li, Jiaying
Ding, Ning
Chen, Jianzhao
Feng, Li
Ma, Shuo
Hu, Chengjun
Dai, Haonan
Wen, Lijun
Jiang, Qingyan
Deng, Jinping
Deng, Ming
Tan, Chengquan
author_facet Wu, Zifang
Rao, Sujuan
Li, Jiaying
Ding, Ning
Chen, Jianzhao
Feng, Li
Ma, Shuo
Hu, Chengjun
Dai, Haonan
Wen, Lijun
Jiang, Qingyan
Deng, Jinping
Deng, Ming
Tan, Chengquan
author_sort Wu, Zifang
collection PubMed
description BACKGROUND: Dietary nucleotides [inclusion adenosine 5’-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. Here, we aimed to explore the effects and the related mechanism of dietary AMP supplementation on food intake, body composition, energy expenditure, and lipid metabolism in male mice. METHODS: 4-week-old C57BL/6 mice (After a 1-wk adaptation) were fed with basal diet and basal diet supplemented with 0.1% AMP, respectively. Animal food intake and body weight were monitored and after 4 weeks all animals were sacrificed to measure the body composition, energy expenditure and lipid metabolism changes. RESULTS: Compared with the control, the 0.1% AMP fed mice showed higher food intake while lower adipose weight. Intriguingly, dietary AMP supplementation was found to stimulate brown adipose tissue thermogenesis as evidenced by the increase in the uncoupling protein-1 level and the core temperature. Moreover, AMP supplementation was shown to promote white adipose tissue lipolysis as indicated by smaller lipid droplet size in mice. These results demonstrate that dietary AMP supplementation could enhance oxygen consumption and energy expenditure. CONCLUSIONS: This study highlights the physiological importance of AMP supplementation in mediating food intake and energy expenditure and suggests its potential as an adjuvant therapy in preventing energy metabolic disorders (mainly obesity and diabetes).
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spelling pubmed-92501342022-07-14 Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice Wu, Zifang Rao, Sujuan Li, Jiaying Ding, Ning Chen, Jianzhao Feng, Li Ma, Shuo Hu, Chengjun Dai, Haonan Wen, Lijun Jiang, Qingyan Deng, Jinping Deng, Ming Tan, Chengquan Food Nutr Res Original Article BACKGROUND: Dietary nucleotides [inclusion adenosine 5’-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. Here, we aimed to explore the effects and the related mechanism of dietary AMP supplementation on food intake, body composition, energy expenditure, and lipid metabolism in male mice. METHODS: 4-week-old C57BL/6 mice (After a 1-wk adaptation) were fed with basal diet and basal diet supplemented with 0.1% AMP, respectively. Animal food intake and body weight were monitored and after 4 weeks all animals were sacrificed to measure the body composition, energy expenditure and lipid metabolism changes. RESULTS: Compared with the control, the 0.1% AMP fed mice showed higher food intake while lower adipose weight. Intriguingly, dietary AMP supplementation was found to stimulate brown adipose tissue thermogenesis as evidenced by the increase in the uncoupling protein-1 level and the core temperature. Moreover, AMP supplementation was shown to promote white adipose tissue lipolysis as indicated by smaller lipid droplet size in mice. These results demonstrate that dietary AMP supplementation could enhance oxygen consumption and energy expenditure. CONCLUSIONS: This study highlights the physiological importance of AMP supplementation in mediating food intake and energy expenditure and suggests its potential as an adjuvant therapy in preventing energy metabolic disorders (mainly obesity and diabetes). Open Academia 2022-06-30 /pmc/articles/PMC9250134/ /pubmed/35844957 http://dx.doi.org/10.29219/fnr.v66.7680 Text en © 2022 Zifang Wu et al. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.
spellingShingle Original Article
Wu, Zifang
Rao, Sujuan
Li, Jiaying
Ding, Ning
Chen, Jianzhao
Feng, Li
Ma, Shuo
Hu, Chengjun
Dai, Haonan
Wen, Lijun
Jiang, Qingyan
Deng, Jinping
Deng, Ming
Tan, Chengquan
Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title_full Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title_fullStr Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title_full_unstemmed Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title_short Dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
title_sort dietary adenosine 5’-monophosphate supplementation increases food intake and remodels energy expenditure in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250134/
https://www.ncbi.nlm.nih.gov/pubmed/35844957
http://dx.doi.org/10.29219/fnr.v66.7680
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