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Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’

BACKGROUND: Aerosol-borne diseases such as COVID-19 may outbreak occasionally in various regions of the world, inevitably resulting in short-term shortage and corresponding reuse of disposable respirators. AIM: To investigate the effective disinfection methods, reusable duration and frequency of N95...

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Autores principales: Zhu, J., Jiang, Q., He, X., Li, X., Wang, L., Zheng, L., Jing, P., Chen, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Healthcare Infection Society. Published by Elsevier Ltd. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250162/
https://www.ncbi.nlm.nih.gov/pubmed/35792275
http://dx.doi.org/10.1016/j.jhin.2022.06.016
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author Zhu, J.
Jiang, Q.
He, X.
Li, X.
Wang, L.
Zheng, L.
Jing, P.
Chen, M.
author_facet Zhu, J.
Jiang, Q.
He, X.
Li, X.
Wang, L.
Zheng, L.
Jing, P.
Chen, M.
author_sort Zhu, J.
collection PubMed
description BACKGROUND: Aerosol-borne diseases such as COVID-19 may outbreak occasionally in various regions of the world, inevitably resulting in short-term shortage and corresponding reuse of disposable respirators. AIM: To investigate the effective disinfection methods, reusable duration and frequency of N95 respirators. METHODS: Based on the self-built respirator simulation test system, and under combinations of experimental conditions of three N95 respirators × 0–200 nm NaCl aerosols × three simulated breathing flow rates (15, 50 and 85 L/min) × two disinfection methods (dry heating and ultraviolet (UV) radiation), this study continuously measured the changes in filtration efficiency of all respirators during multi-cycles of ‘8-h simulated donning + disinfection’ until the penetration reached ≥5%. FINDINGS: Multi-cycles of dry heating and UV radiation treatments on the reused (i.e., multiple 8-h donning) N95 respirators had a minimal effect (<0.5%) on the respirator filtration efficiency, and even at 85 L/min, all tested N95 respirators were able to maintain filtration efficiencies ≥95% for at least 30 h or four reuse cycles of ‘8-h donning + disinfection’, while a lower breathing flow rate (15 L/min) plus the exhalation valve could further extend the N95 respirator's usability duration up to 140 h or 18 reuse cycles of ‘8-h donning + disinfection’. As the respirator wearing time extended, aerosol penetration slowly increased in a quadratic function with a negative second-order coefficient, and the penetration increment during each cycle of 8-h donning was less than 0.9%. CONCLUSION: Multi-cycles of N95 respirator reuse in combination with dry heating or UV irradiation disinfection are feasible.
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spelling pubmed-92501622022-07-05 Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’ Zhu, J. Jiang, Q. He, X. Li, X. Wang, L. Zheng, L. Jing, P. Chen, M. J Hosp Infect Article BACKGROUND: Aerosol-borne diseases such as COVID-19 may outbreak occasionally in various regions of the world, inevitably resulting in short-term shortage and corresponding reuse of disposable respirators. AIM: To investigate the effective disinfection methods, reusable duration and frequency of N95 respirators. METHODS: Based on the self-built respirator simulation test system, and under combinations of experimental conditions of three N95 respirators × 0–200 nm NaCl aerosols × three simulated breathing flow rates (15, 50 and 85 L/min) × two disinfection methods (dry heating and ultraviolet (UV) radiation), this study continuously measured the changes in filtration efficiency of all respirators during multi-cycles of ‘8-h simulated donning + disinfection’ until the penetration reached ≥5%. FINDINGS: Multi-cycles of dry heating and UV radiation treatments on the reused (i.e., multiple 8-h donning) N95 respirators had a minimal effect (<0.5%) on the respirator filtration efficiency, and even at 85 L/min, all tested N95 respirators were able to maintain filtration efficiencies ≥95% for at least 30 h or four reuse cycles of ‘8-h donning + disinfection’, while a lower breathing flow rate (15 L/min) plus the exhalation valve could further extend the N95 respirator's usability duration up to 140 h or 18 reuse cycles of ‘8-h donning + disinfection’. As the respirator wearing time extended, aerosol penetration slowly increased in a quadratic function with a negative second-order coefficient, and the penetration increment during each cycle of 8-h donning was less than 0.9%. CONCLUSION: Multi-cycles of N95 respirator reuse in combination with dry heating or UV irradiation disinfection are feasible. The Healthcare Infection Society. Published by Elsevier Ltd. 2022-09 2022-07-02 /pmc/articles/PMC9250162/ /pubmed/35792275 http://dx.doi.org/10.1016/j.jhin.2022.06.016 Text en © 2022 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhu, J.
Jiang, Q.
He, X.
Li, X.
Wang, L.
Zheng, L.
Jing, P.
Chen, M.
Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title_full Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title_fullStr Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title_full_unstemmed Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title_short Filtration efficiency of N95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
title_sort filtration efficiency of n95 filtering facepiece respirators during multi-cycles of ‘8-hour simulated donning + disinfection’
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250162/
https://www.ncbi.nlm.nih.gov/pubmed/35792275
http://dx.doi.org/10.1016/j.jhin.2022.06.016
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