Cargando…

Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal

BACKGROUND: The preventive and curative strategies of malaria are based on promoting the use of long-lasting insecticidal nets (LLINs) and treating confirmed cases with artemisinin-based combination therapy. These strategies have led to a sharp decline in the burden of malaria, which remains a signi...

Descripción completa

Detalles Bibliográficos
Autores principales: Diouf, El Hadji, Diouf, Mbaye, Dieme, Constentin, Swamidoss, Isabel, Ngom, El Hadji Malick, Senghor, Massila Wagué, Mbaye, Modou, Konaté, Abdoulaye, Coulibaly, Youssouph, Tine, Dome, Dia, Ibrahima, Dotson, Ellen Marie, Faye, Ousmane, Konaté, Lassana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250169/
https://www.ncbi.nlm.nih.gov/pubmed/35780153
http://dx.doi.org/10.1186/s12936-022-04230-6
_version_ 1784739750235602944
author Diouf, El Hadji
Diouf, Mbaye
Dieme, Constentin
Swamidoss, Isabel
Ngom, El Hadji Malick
Senghor, Massila Wagué
Mbaye, Modou
Konaté, Abdoulaye
Coulibaly, Youssouph
Tine, Dome
Dia, Ibrahima
Dotson, Ellen Marie
Faye, Ousmane
Konaté, Lassana
author_facet Diouf, El Hadji
Diouf, Mbaye
Dieme, Constentin
Swamidoss, Isabel
Ngom, El Hadji Malick
Senghor, Massila Wagué
Mbaye, Modou
Konaté, Abdoulaye
Coulibaly, Youssouph
Tine, Dome
Dia, Ibrahima
Dotson, Ellen Marie
Faye, Ousmane
Konaté, Lassana
author_sort Diouf, El Hadji
collection PubMed
description BACKGROUND: The preventive and curative strategies of malaria are based on promoting the use of long-lasting insecticidal nets (LLINs) and treating confirmed cases with artemisinin-based combination therapy. These strategies have led to a sharp decline in the burden of malaria, which remains a significant public health problem in sub-Saharan countries. The objective of this study was to determine and compare the residual efficacy of LLINs recommended by the World Health Organization. METHODS: The study was conducted in six villages in two sites in Senegal located in the Sahelo-Sudanian area of the Thiès region, 70 km from Dakar and in Mbagame, a semi-urban zone in the Senegal River Valley. A census was conducted of all sleeping places in each household to be covered by LLINs. Five brands of LLIN were distributed, and every six months, retention rates, net use, maintenance, physical integrity, insecticide chemical content, and biological efficacy were examined for each type of LLIN. RESULTS: A total of 3012 LLINs were distributed in 1249 households in both sites, with an average coverage rate of 94% (95% CI 92.68–95.3). After 36 months, the average retention rate was 12.5% and this rate was respectively 20.5%, 15.1%, 10%, 7%, and 3% for Olyset Net(®), Dawa Plus(®) 2.0, PermaNet(®) 2.0, NetProtect(®) and Life Net(®), respectively. The proportion of LLINs with holes and the average number of holes per mosquito net increased significantly during each follow-up, with a large predominance of size 1 (small) holes for all types of LLINs distributed. During the three-year follow-up, bioassay mortality rates of a susceptible strain of insectary reared Anopheles coluzzii decreased in the following net types: in Dawa Plus(®) 2.0 (100% to 51.7%), PermaNet(®) 2.0 (96.6% to 83%), and Olyset Net(®) (96.6% to 33.3%). Mortality rates remained at 100% in Life Net(®) over the same time period. After 36 months, the average insecticide content per brand of LLIN decreased by 40.9% for Dawa Plus(®) 2.0, 31% for PermaNet(®) 2.0, 39.6% for NetProtect(®) and 51.9% for Olyset Net(®) and 40.1% for Life Net. CONCLUSIONS: Although some net types retained sufficient insecticidal activity, based on all durability parameters measured, none of the net types survived longer than 2 years.
format Online
Article
Text
id pubmed-9250169
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-92501692022-07-03 Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal Diouf, El Hadji Diouf, Mbaye Dieme, Constentin Swamidoss, Isabel Ngom, El Hadji Malick Senghor, Massila Wagué Mbaye, Modou Konaté, Abdoulaye Coulibaly, Youssouph Tine, Dome Dia, Ibrahima Dotson, Ellen Marie Faye, Ousmane Konaté, Lassana Malar J Research BACKGROUND: The preventive and curative strategies of malaria are based on promoting the use of long-lasting insecticidal nets (LLINs) and treating confirmed cases with artemisinin-based combination therapy. These strategies have led to a sharp decline in the burden of malaria, which remains a significant public health problem in sub-Saharan countries. The objective of this study was to determine and compare the residual efficacy of LLINs recommended by the World Health Organization. METHODS: The study was conducted in six villages in two sites in Senegal located in the Sahelo-Sudanian area of the Thiès region, 70 km from Dakar and in Mbagame, a semi-urban zone in the Senegal River Valley. A census was conducted of all sleeping places in each household to be covered by LLINs. Five brands of LLIN were distributed, and every six months, retention rates, net use, maintenance, physical integrity, insecticide chemical content, and biological efficacy were examined for each type of LLIN. RESULTS: A total of 3012 LLINs were distributed in 1249 households in both sites, with an average coverage rate of 94% (95% CI 92.68–95.3). After 36 months, the average retention rate was 12.5% and this rate was respectively 20.5%, 15.1%, 10%, 7%, and 3% for Olyset Net(®), Dawa Plus(®) 2.0, PermaNet(®) 2.0, NetProtect(®) and Life Net(®), respectively. The proportion of LLINs with holes and the average number of holes per mosquito net increased significantly during each follow-up, with a large predominance of size 1 (small) holes for all types of LLINs distributed. During the three-year follow-up, bioassay mortality rates of a susceptible strain of insectary reared Anopheles coluzzii decreased in the following net types: in Dawa Plus(®) 2.0 (100% to 51.7%), PermaNet(®) 2.0 (96.6% to 83%), and Olyset Net(®) (96.6% to 33.3%). Mortality rates remained at 100% in Life Net(®) over the same time period. After 36 months, the average insecticide content per brand of LLIN decreased by 40.9% for Dawa Plus(®) 2.0, 31% for PermaNet(®) 2.0, 39.6% for NetProtect(®) and 51.9% for Olyset Net(®) and 40.1% for Life Net. CONCLUSIONS: Although some net types retained sufficient insecticidal activity, based on all durability parameters measured, none of the net types survived longer than 2 years. BioMed Central 2022-07-02 /pmc/articles/PMC9250169/ /pubmed/35780153 http://dx.doi.org/10.1186/s12936-022-04230-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Diouf, El Hadji
Diouf, Mbaye
Dieme, Constentin
Swamidoss, Isabel
Ngom, El Hadji Malick
Senghor, Massila Wagué
Mbaye, Modou
Konaté, Abdoulaye
Coulibaly, Youssouph
Tine, Dome
Dia, Ibrahima
Dotson, Ellen Marie
Faye, Ousmane
Konaté, Lassana
Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title_full Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title_fullStr Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title_full_unstemmed Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title_short Evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (LLINs) in Senegal
title_sort evaluation of the residual efficacy and physical durability of five long-lasting insecticidal nets (llins) in senegal
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250169/
https://www.ncbi.nlm.nih.gov/pubmed/35780153
http://dx.doi.org/10.1186/s12936-022-04230-6
work_keys_str_mv AT dioufelhadji evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT dioufmbaye evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT diemeconstentin evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT swamidossisabel evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT ngomelhadjimalick evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT senghormassilawague evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT mbayemodou evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT konateabdoulaye evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT coulibalyyoussouph evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT tinedome evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT diaibrahima evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT dotsonellenmarie evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT fayeousmane evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal
AT konatelassana evaluationoftheresidualefficacyandphysicaldurabilityoffivelonglastinginsecticidalnetsllinsinsenegal