POLE/POLD1 mutation and tumor immunotherapy

POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 exonuclease domain mutations lead to loss of proofreading function, which causes the accumulation of mutant genes in cells. POL...

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Detalles Bibliográficos
Autores principales: Ma, Xiaoting, Dong, Lin, Liu, Xiu, Ou, Kai, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250176/
https://www.ncbi.nlm.nih.gov/pubmed/35780178
http://dx.doi.org/10.1186/s13046-022-02422-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250176/
https://www.ncbi.nlm.nih.gov/pubmed/35780178
http://dx.doi.org/10.1186/s13046-022-02422-1

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