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POLE/POLD1 mutation and tumor immunotherapy

POLE and POLD1 encode the catalytic and proofreading subunits of DNA polymerase ε and polymerase δ, and play important roles in DNA replication and proofreading. POLE/POLD1 exonuclease domain mutations lead to loss of proofreading function, which causes the accumulation of mutant genes in cells. POL...

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Detalles Bibliográficos
Autores principales:	Ma, Xiaoting, Dong, Lin, Liu, Xiu, Ou, Kai, Yang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250176/ https://www.ncbi.nlm.nih.gov/pubmed/35780178 http://dx.doi.org/10.1186/s13046-022-02422-1

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