PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

Transcriptional factor EB (TFEB) is a master regulator of genes required for autophagy and lysosomal function. The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at multiple sites including Ser-211. Here we show tha...

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Detalles Bibliográficos
Autores principales: Hasegawa, Junya, Tokuda, Emi, Yao, Yao, Sasaki, Takehiko, Inoki, Ken, Weisman, Lois S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250387/
https://www.ncbi.nlm.nih.gov/pubmed/35020443
http://dx.doi.org/10.1091/mbc.E21-06-0309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250387/
https://www.ncbi.nlm.nih.gov/pubmed/35020443
http://dx.doi.org/10.1091/mbc.E21-06-0309

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