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TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response

Intestinal epithelial tight junction disruption is a primary contributing factor in alcohol-associated endotoxemia, systemic inflammation, and multiple organ damage. Ethanol and acetaldehyde disrupt tight junctions by elevating intracellular Ca(2+). Here we identify TRPV6, a Ca(2+)-permeable channel...

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Detalles Bibliográficos
Autores principales:	Meena, Avtar S., Shukla, Pradeep K., Bell, Briar, Giorgianni, Francesco, Caires, Rebeca, Fernández-Peña, Carlos, Beranova, Sarka, Aihara, Eitaro, Montrose, Marshall H., Chaib, Mehdi, Makowski, Liza, Neeli, Indira, Radic, Marko Z., Vásquez, Valeria, Jaggar, Jonathan H., Cordero-Morales, Julio F., Rao, RadhaKrishna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250449/ https://www.ncbi.nlm.nih.gov/pubmed/35705057 http://dx.doi.org/10.1016/j.celrep.2022.110937

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