Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer

About 15% of colorectal cancer (CRC) patients have first-degree relatives affected by the same malignancy. However, for most families the cause of familial aggregation of CRC is unknown. To identify novel high-to-moderate-penetrance germline variants underlying CRC susceptibility, we performed whole...

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Detalles Bibliográficos
Autores principales: Skopelitou, Diamanto, Srivastava, Aayushi, Miao, Beiping, Kumar, Abhishek, Dymerska, Dagmara, Paramasivam, Nagarajan, Schlesner, Matthias, Lubinski, Jan, Hemminki, Kari, Försti, Asta, Reddy Bandapalli, Obul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250485/
https://www.ncbi.nlm.nih.gov/pubmed/35562597
http://dx.doi.org/10.1007/s00438-022-01896-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250485/
https://www.ncbi.nlm.nih.gov/pubmed/35562597
http://dx.doi.org/10.1007/s00438-022-01896-0

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