Cargando…

The megabase-scale crossover landscape is largely independent of sequence divergence

Meiotic recombination frequency varies along chromosomes and strongly correlates with sequence divergence. However, the causal relationship between recombination landscapes and polymorphisms is unclear. Here, we characterize the genome-wide recombination landscape in the quasi-absence of polymorphis...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Qichao, Solier, Victor, Walkemeier, Birgit, Durand, Stéphanie, Huettel, Bruno, Schneeberger, Korbinian, Mercier, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250513/
https://www.ncbi.nlm.nih.gov/pubmed/35780220
http://dx.doi.org/10.1038/s41467-022-31509-8
_version_ 1784739830913040384
author Lian, Qichao
Solier, Victor
Walkemeier, Birgit
Durand, Stéphanie
Huettel, Bruno
Schneeberger, Korbinian
Mercier, Raphael
author_facet Lian, Qichao
Solier, Victor
Walkemeier, Birgit
Durand, Stéphanie
Huettel, Bruno
Schneeberger, Korbinian
Mercier, Raphael
author_sort Lian, Qichao
collection PubMed
description Meiotic recombination frequency varies along chromosomes and strongly correlates with sequence divergence. However, the causal relationship between recombination landscapes and polymorphisms is unclear. Here, we characterize the genome-wide recombination landscape in the quasi-absence of polymorphisms, using Arabidopsis thaliana homozygous inbred lines in which a few hundred genetic markers were introduced through mutagenesis. We find that megabase-scale recombination landscapes in inbred lines are strikingly similar to the recombination landscapes in hybrids, with the notable exception of heterozygous large rearrangements where recombination is prevented locally. In addition, the megabase-scale recombination landscape can be largely explained by chromatin features. Our results show that polymorphisms are not a major determinant of the shape of the megabase-scale recombination landscape but rather favour alternative models in which recombination and chromatin shape sequence divergence across the genome.
format Online
Article
Text
id pubmed-9250513
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92505132022-07-04 The megabase-scale crossover landscape is largely independent of sequence divergence Lian, Qichao Solier, Victor Walkemeier, Birgit Durand, Stéphanie Huettel, Bruno Schneeberger, Korbinian Mercier, Raphael Nat Commun Article Meiotic recombination frequency varies along chromosomes and strongly correlates with sequence divergence. However, the causal relationship between recombination landscapes and polymorphisms is unclear. Here, we characterize the genome-wide recombination landscape in the quasi-absence of polymorphisms, using Arabidopsis thaliana homozygous inbred lines in which a few hundred genetic markers were introduced through mutagenesis. We find that megabase-scale recombination landscapes in inbred lines are strikingly similar to the recombination landscapes in hybrids, with the notable exception of heterozygous large rearrangements where recombination is prevented locally. In addition, the megabase-scale recombination landscape can be largely explained by chromatin features. Our results show that polymorphisms are not a major determinant of the shape of the megabase-scale recombination landscape but rather favour alternative models in which recombination and chromatin shape sequence divergence across the genome. Nature Publishing Group UK 2022-07-02 /pmc/articles/PMC9250513/ /pubmed/35780220 http://dx.doi.org/10.1038/s41467-022-31509-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lian, Qichao
Solier, Victor
Walkemeier, Birgit
Durand, Stéphanie
Huettel, Bruno
Schneeberger, Korbinian
Mercier, Raphael
The megabase-scale crossover landscape is largely independent of sequence divergence
title The megabase-scale crossover landscape is largely independent of sequence divergence
title_full The megabase-scale crossover landscape is largely independent of sequence divergence
title_fullStr The megabase-scale crossover landscape is largely independent of sequence divergence
title_full_unstemmed The megabase-scale crossover landscape is largely independent of sequence divergence
title_short The megabase-scale crossover landscape is largely independent of sequence divergence
title_sort megabase-scale crossover landscape is largely independent of sequence divergence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250513/
https://www.ncbi.nlm.nih.gov/pubmed/35780220
http://dx.doi.org/10.1038/s41467-022-31509-8
work_keys_str_mv AT lianqichao themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT soliervictor themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT walkemeierbirgit themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT durandstephanie themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT huettelbruno themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT schneebergerkorbinian themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT mercierraphael themegabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT lianqichao megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT soliervictor megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT walkemeierbirgit megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT durandstephanie megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT huettelbruno megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT schneebergerkorbinian megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence
AT mercierraphael megabasescalecrossoverlandscapeislargelyindependentofsequencedivergence