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Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity

Hydrogels that provide mechanical support and sustainedly release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with surrounding tissue. Here, we report that a hy...

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Autores principales: Freedman, Benjamin R., Kuttler, Andreas, Beckmann, Nicolau, Nam, Sungmin, Kent, Daniel, Schuleit, Michael, Ramazani, Farshad, Accart, Nathalie, Rock, Anna, Li, Jianyu, Kurz, Markus, Fisch, Andreas, Ullrich, Thomas, Hast, Michael W, Tinguely, Yann, Weber, Eckhard, Mooney, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250555/
https://www.ncbi.nlm.nih.gov/pubmed/34980903
http://dx.doi.org/10.1038/s41551-021-00810-0
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author Freedman, Benjamin R.
Kuttler, Andreas
Beckmann, Nicolau
Nam, Sungmin
Kent, Daniel
Schuleit, Michael
Ramazani, Farshad
Accart, Nathalie
Rock, Anna
Li, Jianyu
Kurz, Markus
Fisch, Andreas
Ullrich, Thomas
Hast, Michael W
Tinguely, Yann
Weber, Eckhard
Mooney, David J.
author_facet Freedman, Benjamin R.
Kuttler, Andreas
Beckmann, Nicolau
Nam, Sungmin
Kent, Daniel
Schuleit, Michael
Ramazani, Farshad
Accart, Nathalie
Rock, Anna
Li, Jianyu
Kurz, Markus
Fisch, Andreas
Ullrich, Thomas
Hast, Michael W
Tinguely, Yann
Weber, Eckhard
Mooney, David J.
author_sort Freedman, Benjamin R.
collection PubMed
description Hydrogels that provide mechanical support and sustainedly release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with surrounding tissue. Here, we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J/m2) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings. The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainedly released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype. Hydrogels with ‘Janus’ surfaces and sustained-drug-release functionality could be designed for a range of biomedical applications.
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spelling pubmed-92505552022-10-24 Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity Freedman, Benjamin R. Kuttler, Andreas Beckmann, Nicolau Nam, Sungmin Kent, Daniel Schuleit, Michael Ramazani, Farshad Accart, Nathalie Rock, Anna Li, Jianyu Kurz, Markus Fisch, Andreas Ullrich, Thomas Hast, Michael W Tinguely, Yann Weber, Eckhard Mooney, David J. Nat Biomed Eng Article Hydrogels that provide mechanical support and sustainedly release therapeutics have been used to treat tendon injuries. However, most hydrogels are insufficiently tough, release drugs in bursts, and require cell infiltration or suturing to integrate with surrounding tissue. Here, we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J/m2) to tendon on opposite surfaces of the hydrogel, as we show with porcine and human tendon preparations during cyclic-friction loadings. The hydrogel is biocompatible, strongly adheres to patellar, supraspinatus and Achilles tendons of live rats, boosted healing and reduced scar formation in a rat model of Achilles-tendon rupture, and sustainedly released the corticosteroid triamcinolone acetonide in a rat model of patellar tendon injury, reducing inflammation, modulating chemokine secretion, recruiting tendon stem and progenitor cells, and promoting macrophage polarization to the M2 phenotype. Hydrogels with ‘Janus’ surfaces and sustained-drug-release functionality could be designed for a range of biomedical applications. 2022-10 2022-01-03 /pmc/articles/PMC9250555/ /pubmed/34980903 http://dx.doi.org/10.1038/s41551-021-00810-0 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Freedman, Benjamin R.
Kuttler, Andreas
Beckmann, Nicolau
Nam, Sungmin
Kent, Daniel
Schuleit, Michael
Ramazani, Farshad
Accart, Nathalie
Rock, Anna
Li, Jianyu
Kurz, Markus
Fisch, Andreas
Ullrich, Thomas
Hast, Michael W
Tinguely, Yann
Weber, Eckhard
Mooney, David J.
Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title_full Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title_fullStr Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title_full_unstemmed Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title_short Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
title_sort enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250555/
https://www.ncbi.nlm.nih.gov/pubmed/34980903
http://dx.doi.org/10.1038/s41551-021-00810-0
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