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The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review

BACKGROUND AND OBJECTIVES: Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpos...

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Autores principales: Shakya, Shamatree, Bajracharya, Rashmita, Ledbetter, Leila, Cary, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250659/
https://www.ncbi.nlm.nih.gov/pubmed/35795135
http://dx.doi.org/10.1093/geroni/igac032
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author Shakya, Shamatree
Bajracharya, Rashmita
Ledbetter, Leila
Cary, Michael P
author_facet Shakya, Shamatree
Bajracharya, Rashmita
Ledbetter, Leila
Cary, Michael P
author_sort Shakya, Shamatree
collection PubMed
description BACKGROUND AND OBJECTIVES: Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpose of this review was to appraise and synthesize the current evidence examining the associations between the cardiometabolic risk factors and frailty. RESEARCH DESIGN AND METHODS: Multiple databases, including MEDLINE (via PubMed), Embase (via Elsevier), and Web of Science (via Clarivate), were searched extensively. Studies that examined cardiometabolic risk factors and frailty as main predictors and outcome of interest, respectively, among older adults (≥60 years) were included. The Joanna Briggs Institute critical appraisal tools were used to evaluate the quality of studies. PRISMA (2020) guided this review, and findings were synthesized without meta-analysis. This systematic review was registered in PROSPERO (CRD42021252565). RESULTS: Twelve studies met the eligibility criteria and were included in the review. Abdominal obesity, hyperglycemia, and multiple co-occurring cardiometabolic risk factors were associated with the increased likelihood of frailty in older adults. There was inconsistency across the studies regarding the associations between dyslipidemia, elevated blood pressure, and frailty. DISCUSSION AND IMPLICATIONS: Understanding the association between cardiometabolic risk factors and frailty can have translational benefits in developing tailored interventions for the prevention and management of frailty. More studies are needed to validate predictive and clinically significant associations between single and specific combinations of co-occurring cardiometabolic risk factors and frailty.
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spelling pubmed-92506592022-07-05 The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review Shakya, Shamatree Bajracharya, Rashmita Ledbetter, Leila Cary, Michael P Innov Aging Scholarly Review BACKGROUND AND OBJECTIVES: Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpose of this review was to appraise and synthesize the current evidence examining the associations between the cardiometabolic risk factors and frailty. RESEARCH DESIGN AND METHODS: Multiple databases, including MEDLINE (via PubMed), Embase (via Elsevier), and Web of Science (via Clarivate), were searched extensively. Studies that examined cardiometabolic risk factors and frailty as main predictors and outcome of interest, respectively, among older adults (≥60 years) were included. The Joanna Briggs Institute critical appraisal tools were used to evaluate the quality of studies. PRISMA (2020) guided this review, and findings were synthesized without meta-analysis. This systematic review was registered in PROSPERO (CRD42021252565). RESULTS: Twelve studies met the eligibility criteria and were included in the review. Abdominal obesity, hyperglycemia, and multiple co-occurring cardiometabolic risk factors were associated with the increased likelihood of frailty in older adults. There was inconsistency across the studies regarding the associations between dyslipidemia, elevated blood pressure, and frailty. DISCUSSION AND IMPLICATIONS: Understanding the association between cardiometabolic risk factors and frailty can have translational benefits in developing tailored interventions for the prevention and management of frailty. More studies are needed to validate predictive and clinically significant associations between single and specific combinations of co-occurring cardiometabolic risk factors and frailty. Oxford University Press 2022-05-25 /pmc/articles/PMC9250659/ /pubmed/35795135 http://dx.doi.org/10.1093/geroni/igac032 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Scholarly Review
Shakya, Shamatree
Bajracharya, Rashmita
Ledbetter, Leila
Cary, Michael P
The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title_full The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title_fullStr The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title_full_unstemmed The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title_short The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review
title_sort association between cardiometabolic risk factors and frailty in older adults: a systematic review
topic Scholarly Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250659/
https://www.ncbi.nlm.nih.gov/pubmed/35795135
http://dx.doi.org/10.1093/geroni/igac032
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