Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

BACKGROUND: Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer’s disease (AD). In recent years, impairment of autophagy has been identified as another important feature contributing to AD progre...

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Detalles Bibliográficos
Autores principales: Freitag, Kiara, Sterczyk, Nele, Wendlinger, Sarah, Obermayer, Benedikt, Schulz, Julia, Farztdinov, Vadim, Mülleder, Michael, Ralser, Markus, Houtman, Judith, Fleck, Lara, Braeuning, Caroline, Sansevrino, Roberto, Hoffmann, Christian, Milovanovic, Dragomir, Sigrist, Stephan J., Conrad, Thomas, Beule, Dieter, Heppner, Frank L., Jendrach, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250727/
https://www.ncbi.nlm.nih.gov/pubmed/35780157
http://dx.doi.org/10.1186/s12974-022-02534-7

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