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Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to severe joint damage, disability and mortality. Quercetin (QUE) is a natural flavonoid that is ubiquitous in fruits and vegetables. This article reviews the effect of QUE on articular and extra-articular manifestations of RA i...

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Autores principales: Tang, Mengshi, Zeng, Yan, Peng, Weijun, Xie, Xi, Yang, Yongyu, Ji, Biting, Li, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250769/
https://www.ncbi.nlm.nih.gov/pubmed/35791403
http://dx.doi.org/10.2147/DDDT.S364759
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author Tang, Mengshi
Zeng, Yan
Peng, Weijun
Xie, Xi
Yang, Yongyu
Ji, Biting
Li, Fen
author_facet Tang, Mengshi
Zeng, Yan
Peng, Weijun
Xie, Xi
Yang, Yongyu
Ji, Biting
Li, Fen
author_sort Tang, Mengshi
collection PubMed
description Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to severe joint damage, disability and mortality. Quercetin (QUE) is a natural flavonoid that is ubiquitous in fruits and vegetables. This article reviews the effect of QUE on articular and extra-articular manifestations of RA in vitro and in vivo. In general, for articular manifestations, QUE inhibited synovial membrane inflammation by reducing inflammatory cytokines and mediators, decreasing oxidative stress, inhibiting proliferation, migration and invasion, and promoting apoptosis of fibroblast-like synoviocytes (FLS), regulated autoimmune response through modulating Th17/Treg imbalance and Th17 cells differentiation, reducing autoantibodies levels and regulating ectonucleoside triphosphate diphosphohydrolase (E-NTPDase)/ectoadenosine deaminase (E-ADA) activities, reduced bony damage via lowering matrix metalloproteinase (MMP)-1, MMP-3, receptor activator of nuclear factor kappa B ligand (RANKL) expression and osteoclasts formation. For extra-articular manifestations, QUE could reverse the neurodegenerative processes of the enteric nervous system (ENS) and exhibited cytoprotective, genoprotective and hepatoprotective effects. In addition, we also summarize some contradictory experimental results and explore the possibility for these differences to form a sound basis for the clinical application of QUE for RA.
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spelling pubmed-92507692022-07-04 Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis Tang, Mengshi Zeng, Yan Peng, Weijun Xie, Xi Yang, Yongyu Ji, Biting Li, Fen Drug Des Devel Ther Review Rheumatoid arthritis (RA) is a chronic autoimmune disease that can lead to severe joint damage, disability and mortality. Quercetin (QUE) is a natural flavonoid that is ubiquitous in fruits and vegetables. This article reviews the effect of QUE on articular and extra-articular manifestations of RA in vitro and in vivo. In general, for articular manifestations, QUE inhibited synovial membrane inflammation by reducing inflammatory cytokines and mediators, decreasing oxidative stress, inhibiting proliferation, migration and invasion, and promoting apoptosis of fibroblast-like synoviocytes (FLS), regulated autoimmune response through modulating Th17/Treg imbalance and Th17 cells differentiation, reducing autoantibodies levels and regulating ectonucleoside triphosphate diphosphohydrolase (E-NTPDase)/ectoadenosine deaminase (E-ADA) activities, reduced bony damage via lowering matrix metalloproteinase (MMP)-1, MMP-3, receptor activator of nuclear factor kappa B ligand (RANKL) expression and osteoclasts formation. For extra-articular manifestations, QUE could reverse the neurodegenerative processes of the enteric nervous system (ENS) and exhibited cytoprotective, genoprotective and hepatoprotective effects. In addition, we also summarize some contradictory experimental results and explore the possibility for these differences to form a sound basis for the clinical application of QUE for RA. Dove 2022-06-29 /pmc/articles/PMC9250769/ /pubmed/35791403 http://dx.doi.org/10.2147/DDDT.S364759 Text en © 2022 Tang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Tang, Mengshi
Zeng, Yan
Peng, Weijun
Xie, Xi
Yang, Yongyu
Ji, Biting
Li, Fen
Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title_full Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title_fullStr Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title_full_unstemmed Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title_short Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
title_sort pharmacological aspects of natural quercetin in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250769/
https://www.ncbi.nlm.nih.gov/pubmed/35791403
http://dx.doi.org/10.2147/DDDT.S364759
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