A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient

Aggressive natural killer cell leukemia (ANKL) is a rare neoplastic malignancy, especially in pediatric populations with very few cases reported in the literature. It commonly presents with a rapidly declining clinical course and has a median survival of two months. We report the case of a 15-year-o...

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Autores principales: Donato, Umberto M, Shoeleh, Celeste, Galligan, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250800/
https://www.ncbi.nlm.nih.gov/pubmed/35795499
http://dx.doi.org/10.7759/cureus.25634
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author Donato, Umberto M
Shoeleh, Celeste
Galligan, Andrew
author_facet Donato, Umberto M
Shoeleh, Celeste
Galligan, Andrew
author_sort Donato, Umberto M
collection PubMed
description Aggressive natural killer cell leukemia (ANKL) is a rare neoplastic malignancy, especially in pediatric populations with very few cases reported in the literature. It commonly presents with a rapidly declining clinical course and has a median survival of two months. We report the case of a 15-year-old female who presented with fever, hepatosplenomegaly, hemophagocytosis, and disseminated intravascular coagulation (DIC). The patient was ultimately diagnosed with ANKL but died after developing multiorgan failure and DIC prior to the initiation of any treatment. In this case report, we review and discuss the literature concerning the diagnosis and treatment of ANKL in pediatric patients.
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spelling pubmed-92508002022-07-05 A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient Donato, Umberto M Shoeleh, Celeste Galligan, Andrew Cureus Pediatrics Aggressive natural killer cell leukemia (ANKL) is a rare neoplastic malignancy, especially in pediatric populations with very few cases reported in the literature. It commonly presents with a rapidly declining clinical course and has a median survival of two months. We report the case of a 15-year-old female who presented with fever, hepatosplenomegaly, hemophagocytosis, and disseminated intravascular coagulation (DIC). The patient was ultimately diagnosed with ANKL but died after developing multiorgan failure and DIC prior to the initiation of any treatment. In this case report, we review and discuss the literature concerning the diagnosis and treatment of ANKL in pediatric patients. Cureus 2022-06-03 /pmc/articles/PMC9250800/ /pubmed/35795499 http://dx.doi.org/10.7759/cureus.25634 Text en Copyright © 2022, Donato et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Donato, Umberto M
Shoeleh, Celeste
Galligan, Andrew
A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title_full A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title_fullStr A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title_full_unstemmed A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title_short A Case Report on Aggressive Natural Killer Cell Leukemia in a Pediatric Patient
title_sort case report on aggressive natural killer cell leukemia in a pediatric patient
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250800/
https://www.ncbi.nlm.nih.gov/pubmed/35795499
http://dx.doi.org/10.7759/cureus.25634
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