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Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways
The innate immune response is the first-line host defense against pathogens. Cytosolic nucleic acids, including both DNA and RNA, represent a special type of danger signal to initiate an innate immune response. Activation of cytosolic nucleic acid sensors is tightly controlled in order to achieve th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250978/ https://www.ncbi.nlm.nih.gov/pubmed/35795661 http://dx.doi.org/10.3389/fimmu.2022.898724 |
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author | Deng, Yu Wang, Ying Li, Lupeng Miao, Edward A. Liu, Pengda |
author_facet | Deng, Yu Wang, Ying Li, Lupeng Miao, Edward A. Liu, Pengda |
author_sort | Deng, Yu |
collection | PubMed |
description | The innate immune response is the first-line host defense against pathogens. Cytosolic nucleic acids, including both DNA and RNA, represent a special type of danger signal to initiate an innate immune response. Activation of cytosolic nucleic acid sensors is tightly controlled in order to achieve the high sensitivity needed to combat infection while simultaneously preventing false activation that leads to pathologic inflammatory diseases. In this review, we focus on post-translational modifications of key cytosolic nucleic acid sensors that can reversibly or irreversibly control these sensor functions. We will describe phosphorylation, ubiquitination, SUMOylation, neddylation, acetylation, methylation, succinylation, glutamylation, amidation, palmitoylation, and oxidation modifications events (including modified residues, modifying enzymes, and modification function). Together, these post-translational regulatory modifications on key cytosolic DNA/RNA sensing pathway members reveal a complicated yet elegantly controlled multilayer regulator network to govern innate immune activation. |
format | Online Article Text |
id | pubmed-9250978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92509782022-07-05 Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways Deng, Yu Wang, Ying Li, Lupeng Miao, Edward A. Liu, Pengda Front Immunol Immunology The innate immune response is the first-line host defense against pathogens. Cytosolic nucleic acids, including both DNA and RNA, represent a special type of danger signal to initiate an innate immune response. Activation of cytosolic nucleic acid sensors is tightly controlled in order to achieve the high sensitivity needed to combat infection while simultaneously preventing false activation that leads to pathologic inflammatory diseases. In this review, we focus on post-translational modifications of key cytosolic nucleic acid sensors that can reversibly or irreversibly control these sensor functions. We will describe phosphorylation, ubiquitination, SUMOylation, neddylation, acetylation, methylation, succinylation, glutamylation, amidation, palmitoylation, and oxidation modifications events (including modified residues, modifying enzymes, and modification function). Together, these post-translational regulatory modifications on key cytosolic DNA/RNA sensing pathway members reveal a complicated yet elegantly controlled multilayer regulator network to govern innate immune activation. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9250978/ /pubmed/35795661 http://dx.doi.org/10.3389/fimmu.2022.898724 Text en Copyright © 2022 Deng, Wang, Li, Miao and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Deng, Yu Wang, Ying Li, Lupeng Miao, Edward A. Liu, Pengda Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title | Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title_full | Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title_fullStr | Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title_full_unstemmed | Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title_short | Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways |
title_sort | post-translational modifications of proteins in cytosolic nucleic acid sensing signaling pathways |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250978/ https://www.ncbi.nlm.nih.gov/pubmed/35795661 http://dx.doi.org/10.3389/fimmu.2022.898724 |
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