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Loss of Gut Barrier Integrity In Lupus

Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains unknown. Increased gut permeability has been reported in lupus patients, yet whether it promotes or results from lupus progression is unclear. Recent studies indicate that an impaired intestinal barrier allows the...

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Autores principales: Ma, Longhuan, Morel, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250981/
https://www.ncbi.nlm.nih.gov/pubmed/35795671
http://dx.doi.org/10.3389/fimmu.2022.919792
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author Ma, Longhuan
Morel, Laurence
author_facet Ma, Longhuan
Morel, Laurence
author_sort Ma, Longhuan
collection PubMed
description Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains unknown. Increased gut permeability has been reported in lupus patients, yet whether it promotes or results from lupus progression is unclear. Recent studies indicate that an impaired intestinal barrier allows the translocation of bacteria and bacterial components into systemic organs, increasing immune cell activation and autoantibody generation. Indeed, induced gut leakage in a mouse model of lupus enhanced disease characteristics, including the production of anti-dsDNA antibody, serum IL-6 as well as cell apoptosis. Gut microbiota dysbiosis has been suggested to be one of the factors that decreases gut barrier integrity by outgrowing harmful bacteria and their products, or by perturbation of gut immune homeostasis, which in turn affects gut barrier integrity. The restoration of microbial balance eliminates gut leakage in mice, further confirming the role of microbiota in maintaining gut barrier integrity. In this review, we discuss recent advances on the association between microbiota dysbiosis and leaky gut, as well as their influences on the progression of lupus. The modifications on host microbiota and gut integrity may offer insights into the development of new lupus treatment.
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spelling pubmed-92509812022-07-05 Loss of Gut Barrier Integrity In Lupus Ma, Longhuan Morel, Laurence Front Immunol Immunology Systemic Lupus Erythematosus is a complex autoimmune disease and its etiology remains unknown. Increased gut permeability has been reported in lupus patients, yet whether it promotes or results from lupus progression is unclear. Recent studies indicate that an impaired intestinal barrier allows the translocation of bacteria and bacterial components into systemic organs, increasing immune cell activation and autoantibody generation. Indeed, induced gut leakage in a mouse model of lupus enhanced disease characteristics, including the production of anti-dsDNA antibody, serum IL-6 as well as cell apoptosis. Gut microbiota dysbiosis has been suggested to be one of the factors that decreases gut barrier integrity by outgrowing harmful bacteria and their products, or by perturbation of gut immune homeostasis, which in turn affects gut barrier integrity. The restoration of microbial balance eliminates gut leakage in mice, further confirming the role of microbiota in maintaining gut barrier integrity. In this review, we discuss recent advances on the association between microbiota dysbiosis and leaky gut, as well as their influences on the progression of lupus. The modifications on host microbiota and gut integrity may offer insights into the development of new lupus treatment. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9250981/ /pubmed/35795671 http://dx.doi.org/10.3389/fimmu.2022.919792 Text en Copyright © 2022 Ma and Morel https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ma, Longhuan
Morel, Laurence
Loss of Gut Barrier Integrity In Lupus
title Loss of Gut Barrier Integrity In Lupus
title_full Loss of Gut Barrier Integrity In Lupus
title_fullStr Loss of Gut Barrier Integrity In Lupus
title_full_unstemmed Loss of Gut Barrier Integrity In Lupus
title_short Loss of Gut Barrier Integrity In Lupus
title_sort loss of gut barrier integrity in lupus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9250981/
https://www.ncbi.nlm.nih.gov/pubmed/35795671
http://dx.doi.org/10.3389/fimmu.2022.919792
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