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High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6

OBJECTIVES: CDC45 is the core component of CMG (CDC45‐MCMs‐GINS) complex that plays important role in the initial step of DNA replication in eukaryotic cells. The expression level of cdc45 is under the critical control for the accurate cell cycle progression. Loss‐of‐function of cdc45 has been demon...

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Detalles Bibliográficos
Autores principales: Fu, Yuanyuan, Lv, Zhiyi, Kong, Deqing, Fan, Yuping, Dong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251052/
https://www.ncbi.nlm.nih.gov/pubmed/35642733
http://dx.doi.org/10.1111/cpr.13257