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Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate
CD4(+) T cells differentiate towards different subpopulations through the regulation of lineage-specific cytokines and transcription factors, which flexibly respond to various immune challenges. However, considerable work has demonstrated that the CD4(+) T-cell differentiation mechanism is complex a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251064/ https://www.ncbi.nlm.nih.gov/pubmed/35794862 http://dx.doi.org/10.3389/fcell.2022.831215 |
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author | Liu, Chang Zhang, Yanli Ma, Zhanchuan Yi, Huanfa |
author_facet | Liu, Chang Zhang, Yanli Ma, Zhanchuan Yi, Huanfa |
author_sort | Liu, Chang |
collection | PubMed |
description | CD4(+) T cells differentiate towards different subpopulations through the regulation of lineage-specific cytokines and transcription factors, which flexibly respond to various immune challenges. However, considerable work has demonstrated that the CD4(+) T-cell differentiation mechanism is complex and not limited to transcription factors and cytokines. Long noncoding RNAs (lncRNAs) are RNA molecules with lengths exceeding 200 base pairs that regulate various biological processes and genes. LncRNAs have been found to conciliate the plasticity of CD4(+) T-cell differentiation. Then, we focused on lncRNAs involved in CD4(+) T-cell differentiation and enlisted some molecular thought into the plasticity and functional heterogeneity of CD4(+) T cells. Furthermore, elucidating how lncRNAs modulate CD4(+) T-cell differentiation in disparate immune diseases may provide a basis for the pathological mechanism of immune-mediated diseases. |
format | Online Article Text |
id | pubmed-9251064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92510642022-07-05 Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate Liu, Chang Zhang, Yanli Ma, Zhanchuan Yi, Huanfa Front Cell Dev Biol Cell and Developmental Biology CD4(+) T cells differentiate towards different subpopulations through the regulation of lineage-specific cytokines and transcription factors, which flexibly respond to various immune challenges. However, considerable work has demonstrated that the CD4(+) T-cell differentiation mechanism is complex and not limited to transcription factors and cytokines. Long noncoding RNAs (lncRNAs) are RNA molecules with lengths exceeding 200 base pairs that regulate various biological processes and genes. LncRNAs have been found to conciliate the plasticity of CD4(+) T-cell differentiation. Then, we focused on lncRNAs involved in CD4(+) T-cell differentiation and enlisted some molecular thought into the plasticity and functional heterogeneity of CD4(+) T cells. Furthermore, elucidating how lncRNAs modulate CD4(+) T-cell differentiation in disparate immune diseases may provide a basis for the pathological mechanism of immune-mediated diseases. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9251064/ /pubmed/35794862 http://dx.doi.org/10.3389/fcell.2022.831215 Text en Copyright © 2022 Liu, Zhang, Ma and Yi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Liu, Chang Zhang, Yanli Ma, Zhanchuan Yi, Huanfa Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title | Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title_full | Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title_fullStr | Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title_full_unstemmed | Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title_short | Long Noncoding RNAs as Orchestrators of CD4(+) T-Cell Fate |
title_sort | long noncoding rnas as orchestrators of cd4(+) t-cell fate |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251064/ https://www.ncbi.nlm.nih.gov/pubmed/35794862 http://dx.doi.org/10.3389/fcell.2022.831215 |
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