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Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC

ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) databas...

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Autores principales: Yue, Yanping, Wu, Yumeng, Zhao, Dakun, Wu, Biao, Wu, Xuming, Liu, Jibin, Yang, Lei, Shen, Aiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251093/
https://www.ncbi.nlm.nih.gov/pubmed/35795311
http://dx.doi.org/10.1155/2022/4541571
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author Yue, Yanping
Wu, Yumeng
Zhao, Dakun
Wu, Biao
Wu, Xuming
Liu, Jibin
Yang, Lei
Shen, Aiguo
author_facet Yue, Yanping
Wu, Yumeng
Zhao, Dakun
Wu, Biao
Wu, Xuming
Liu, Jibin
Yang, Lei
Shen, Aiguo
author_sort Yue, Yanping
collection PubMed
description ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets.
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spelling pubmed-92510932022-07-05 Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC Yue, Yanping Wu, Yumeng Zhao, Dakun Wu, Biao Wu, Xuming Liu, Jibin Yang, Lei Shen, Aiguo Biomed Res Int Research Article ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets. Hindawi 2022-06-26 /pmc/articles/PMC9251093/ /pubmed/35795311 http://dx.doi.org/10.1155/2022/4541571 Text en Copyright © 2022 Yanping Yue et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yue, Yanping
Wu, Yumeng
Zhao, Dakun
Wu, Biao
Wu, Xuming
Liu, Jibin
Yang, Lei
Shen, Aiguo
Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title_full Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title_fullStr Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title_full_unstemmed Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title_short Pan-Cancer Analysis Predicts the Immunological and Prognostic Role of ZC3H12C in KIRC
title_sort pan-cancer analysis predicts the immunological and prognostic role of zc3h12c in kirc
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251093/
https://www.ncbi.nlm.nih.gov/pubmed/35795311
http://dx.doi.org/10.1155/2022/4541571
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