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Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification

Calcific aortic valve disease (CAVD) is linked to high mortality. Melatonin inhibits nuclear factor-kappa B (NF-κB)/cyclic AMP response element-binding protein (CREB), contributing to CAVD progression. This study determined the role of melatonin/MT1/MT2 signaling in valvular interstitial cell (VIC)...

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Detalles Bibliográficos
Autores principales:	Li, Shao-Jung, Cheng, Wan-Li, Kao, Yu-Hsun, Chung, Cheng-Chih, Trang, Nguyen Ngoc, Chen, Yi-Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251177/ https://www.ncbi.nlm.nih.gov/pubmed/35795373 http://dx.doi.org/10.3389/fcvm.2022.885293

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