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Treatment of Intervertebral Disc Degeneration

Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, mal...

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Autores principales: Xin, Jingguo, Wang, Yongjie, Zheng, Zhi, Wang, Shuo, Na, Shibo, Zhang, Shaokun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251272/
https://www.ncbi.nlm.nih.gov/pubmed/35486489
http://dx.doi.org/10.1111/os.13254
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author Xin, Jingguo
Wang, Yongjie
Zheng, Zhi
Wang, Shuo
Na, Shibo
Zhang, Shaokun
author_facet Xin, Jingguo
Wang, Yongjie
Zheng, Zhi
Wang, Shuo
Na, Shibo
Zhang, Shaokun
author_sort Xin, Jingguo
collection PubMed
description Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on. The pathological changes of IDD are mainly composed of the senescence and apoptosis of nucleus pulposus cells (NPCs), the progressive degeneration of extracellular matrix (ECM), the fibrosis of annulus fibrosus (AF), and the inflammatory response. At present, IDD can be treated by conservative treatment and surgical treatment based on patients' symptoms. However, all of these can only release the pain but cannot reverse IDD and reconstruct the mechanical function of the spine. The latest research is moving towards the field of biotherapy. Mesenchymal stem cells (MSCs) are regard as the potential therapy of IDD because of their ability to self‐renew and differentiate into a variety of tissues. Moreover, the non‐coding RNAs (ncRNAs) are found to regulate many vital processes in IDD. There have been many successes in the in vitro and animal studies of using biotherapy to treat IDD, but how to transform the experimental data to real therapy which can apply to humans is still a challenge. This article mainly reviews the treatment strategies and research progress of IDD and indicates that there are many problems that need to be solved if the new biotherapy is to be applied to clinical treatment of IDD. This will provide reference and guidance for clinical treatment and research direction of IDD.
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spelling pubmed-92512722022-07-05 Treatment of Intervertebral Disc Degeneration Xin, Jingguo Wang, Yongjie Zheng, Zhi Wang, Shuo Na, Shibo Zhang, Shaokun Orthop Surg Review Articles Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high social and economic costs. IDD results from many factors, including genetic factors, aging, mechanical injury, malnutrition, and so on. The pathological changes of IDD are mainly composed of the senescence and apoptosis of nucleus pulposus cells (NPCs), the progressive degeneration of extracellular matrix (ECM), the fibrosis of annulus fibrosus (AF), and the inflammatory response. At present, IDD can be treated by conservative treatment and surgical treatment based on patients' symptoms. However, all of these can only release the pain but cannot reverse IDD and reconstruct the mechanical function of the spine. The latest research is moving towards the field of biotherapy. Mesenchymal stem cells (MSCs) are regard as the potential therapy of IDD because of their ability to self‐renew and differentiate into a variety of tissues. Moreover, the non‐coding RNAs (ncRNAs) are found to regulate many vital processes in IDD. There have been many successes in the in vitro and animal studies of using biotherapy to treat IDD, but how to transform the experimental data to real therapy which can apply to humans is still a challenge. This article mainly reviews the treatment strategies and research progress of IDD and indicates that there are many problems that need to be solved if the new biotherapy is to be applied to clinical treatment of IDD. This will provide reference and guidance for clinical treatment and research direction of IDD. John Wiley & Sons Australia, Ltd 2022-04-29 /pmc/articles/PMC9251272/ /pubmed/35486489 http://dx.doi.org/10.1111/os.13254 Text en © 2022 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Xin, Jingguo
Wang, Yongjie
Zheng, Zhi
Wang, Shuo
Na, Shibo
Zhang, Shaokun
Treatment of Intervertebral Disc Degeneration
title Treatment of Intervertebral Disc Degeneration
title_full Treatment of Intervertebral Disc Degeneration
title_fullStr Treatment of Intervertebral Disc Degeneration
title_full_unstemmed Treatment of Intervertebral Disc Degeneration
title_short Treatment of Intervertebral Disc Degeneration
title_sort treatment of intervertebral disc degeneration
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251272/
https://www.ncbi.nlm.nih.gov/pubmed/35486489
http://dx.doi.org/10.1111/os.13254
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