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Characterization of radicals in polysorbate 80 using electron paramagnetic resonance (EPR) spectroscopy and spin trapping

Polysorbates are an important class of nonionic surfactants that are widely used to stabilize biopharmaceuticals. The degradation of polysorbate 20 and 80 and the related particle formation in biologics are heavily discussed in the pharmaceutical community. Although a lot of experimental effort was...

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Detalles Bibliográficos
Autores principales:	Mittag, Judith J., Trutschel, Marie-Luise, Kruschwitz, Helen, Mäder, Karsten, Buske, Julia, Garidel, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251573/ https://www.ncbi.nlm.nih.gov/pubmed/35795322 http://dx.doi.org/10.1016/j.ijpx.2022.100123

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