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Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

BACKGROUND: Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms that modulate cell metabolism during anti-tumor therapy. We set out to define ho...

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Detalles Bibliográficos
Autores principales:	Marx, Christian, Sonnemann, Jürgen, Maddocks, Oliver D. K., Marx-Blümel, Lisa, Beyer, Mandy, Hoelzer, Doerte, Thierbach, René, Maletzki, Claudia, Linnebacher, Michael, Heinzel, Thorsten, Krämer, Oliver H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251592/ https://www.ncbi.nlm.nih.gov/pubmed/35787728 http://dx.doi.org/10.1186/s40170-022-00286-9

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