Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease

An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak...

Descripción completa

Detalles Bibliográficos
Autores principales: Dedrick, Rebekah M, Freeman, Krista G, Nguyen, Jan A, Bahadirli-Talbott, Asli, Cardin, Mitchell E, Cristinziano, Madison, Smith, Bailey E, Jeong, Soowan, Ignatius, Elisa H, Lin, Cheng Ting, Cohen, Keira A, Hatfull, Graham F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251665/
https://www.ncbi.nlm.nih.gov/pubmed/35794944
http://dx.doi.org/10.1093/ofid/ofac194
Descripción
Sumario:An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.

Ejemplares similares