Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease

An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak...

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Autores principales: Dedrick, Rebekah M, Freeman, Krista G, Nguyen, Jan A, Bahadirli-Talbott, Asli, Cardin, Mitchell E, Cristinziano, Madison, Smith, Bailey E, Jeong, Soowan, Ignatius, Elisa H, Lin, Cheng Ting, Cohen, Keira A, Hatfull, Graham F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251665/
https://www.ncbi.nlm.nih.gov/pubmed/35794944
http://dx.doi.org/10.1093/ofid/ofac194
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author Dedrick, Rebekah M
Freeman, Krista G
Nguyen, Jan A
Bahadirli-Talbott, Asli
Cardin, Mitchell E
Cristinziano, Madison
Smith, Bailey E
Jeong, Soowan
Ignatius, Elisa H
Lin, Cheng Ting
Cohen, Keira A
Hatfull, Graham F
author_facet Dedrick, Rebekah M
Freeman, Krista G
Nguyen, Jan A
Bahadirli-Talbott, Asli
Cardin, Mitchell E
Cristinziano, Madison
Smith, Bailey E
Jeong, Soowan
Ignatius, Elisa H
Lin, Cheng Ting
Cohen, Keira A
Hatfull, Graham F
author_sort Dedrick, Rebekah M
collection PubMed
description An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.
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spelling pubmed-92516652022-07-05 Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease Dedrick, Rebekah M Freeman, Krista G Nguyen, Jan A Bahadirli-Talbott, Asli Cardin, Mitchell E Cristinziano, Madison Smith, Bailey E Jeong, Soowan Ignatius, Elisa H Lin, Cheng Ting Cohen, Keira A Hatfull, Graham F Open Forum Infect Dis Brief Report An elderly man with refractory Mycobacterium abscessus lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced Mycobacterium burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor. Oxford University Press 2022-04-12 /pmc/articles/PMC9251665/ /pubmed/35794944 http://dx.doi.org/10.1093/ofid/ofac194 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Dedrick, Rebekah M
Freeman, Krista G
Nguyen, Jan A
Bahadirli-Talbott, Asli
Cardin, Mitchell E
Cristinziano, Madison
Smith, Bailey E
Jeong, Soowan
Ignatius, Elisa H
Lin, Cheng Ting
Cohen, Keira A
Hatfull, Graham F
Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title_full Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title_fullStr Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title_full_unstemmed Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title_short Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease
title_sort nebulized bacteriophage in a patient with refractory mycobacterium abscessus lung disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251665/
https://www.ncbi.nlm.nih.gov/pubmed/35794944
http://dx.doi.org/10.1093/ofid/ofac194
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