Palladium-Catalyzed trans-Hydroalkoxylation: Counterintuitive Use of an Aryl Iodide Additive to Promote C–H Bond Formation

[Image: see text] We report an enantioselective palladium-catalyzed trans-hydroalkoxylation of propargylic amines with a trifluoroacetaldehyde-derived tether to build chiral oxazolidines. Diastereoselective hydrogenation using a heterogeneous palladium catalyst then gave access to protected benzylic...

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Detalles Bibliográficos
Autores principales: Das, Ashis, Buzzetti, Luca, Puriņš, Mikus, Waser, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251722/
https://www.ncbi.nlm.nih.gov/pubmed/35799768
http://dx.doi.org/10.1021/acscatal.2c01809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251722/
https://www.ncbi.nlm.nih.gov/pubmed/35799768
http://dx.doi.org/10.1021/acscatal.2c01809

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