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Membrane translocation of folded proteins
An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251779/ https://www.ncbi.nlm.nih.gov/pubmed/35671825 http://dx.doi.org/10.1016/j.jbc.2022.102107 |
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author | Pei, Dehua Dalbey, Ross E. |
author_facet | Pei, Dehua Dalbey, Ross E. |
author_sort | Pei, Dehua |
collection | PubMed |
description | An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established or likely to involve the membrane translocation of folded proteins, such as protein export by the twin-arginine translocation system in bacteria and chloroplasts, unconventional protein secretion and protein import into the peroxisome in eukaryotes, and the cytosolic entry of proteins (e.g., bacterial toxins) and viruses into eukaryotes. We also discuss the various mechanistic models that have previously been proposed for the membrane translocation of folded proteins including pore/channel formation, local membrane disruption, membrane thinning, and transport by membrane vesicles. Finally, we introduce a newly discovered vesicular transport mechanism, vesicle budding and collapse, and present evidence that vesicle budding and collapse may represent a unifying mechanism that drives some (and potentially all) of folded protein translocation processes. |
format | Online Article Text |
id | pubmed-9251779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-92517792022-07-06 Membrane translocation of folded proteins Pei, Dehua Dalbey, Ross E. J Biol Chem JBC Reviews An ever-increasing number of proteins have been shown to translocate across various membranes of bacterial as well as eukaryotic cells in their folded states as a part of physiological and/or pathophysiological processes. Herein, we provide an overview of the systems/processes that are established or likely to involve the membrane translocation of folded proteins, such as protein export by the twin-arginine translocation system in bacteria and chloroplasts, unconventional protein secretion and protein import into the peroxisome in eukaryotes, and the cytosolic entry of proteins (e.g., bacterial toxins) and viruses into eukaryotes. We also discuss the various mechanistic models that have previously been proposed for the membrane translocation of folded proteins including pore/channel formation, local membrane disruption, membrane thinning, and transport by membrane vesicles. Finally, we introduce a newly discovered vesicular transport mechanism, vesicle budding and collapse, and present evidence that vesicle budding and collapse may represent a unifying mechanism that drives some (and potentially all) of folded protein translocation processes. American Society for Biochemistry and Molecular Biology 2022-06-04 /pmc/articles/PMC9251779/ /pubmed/35671825 http://dx.doi.org/10.1016/j.jbc.2022.102107 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | JBC Reviews Pei, Dehua Dalbey, Ross E. Membrane translocation of folded proteins |
title | Membrane translocation of folded proteins |
title_full | Membrane translocation of folded proteins |
title_fullStr | Membrane translocation of folded proteins |
title_full_unstemmed | Membrane translocation of folded proteins |
title_short | Membrane translocation of folded proteins |
title_sort | membrane translocation of folded proteins |
topic | JBC Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251779/ https://www.ncbi.nlm.nih.gov/pubmed/35671825 http://dx.doi.org/10.1016/j.jbc.2022.102107 |
work_keys_str_mv | AT peidehua membranetranslocationoffoldedproteins AT dalbeyrosse membranetranslocationoffoldedproteins |