TET2–BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter

Ascl2 has been shown to be involved in tumorigenesis in colorectal cancer (CRC), although its epigenetic regulatory mechanism is largely unknown. Here, we found that methylation of the Ascl2 promoter (bp -1670 ∼ -1139) was significantly increased compared to the other regions of the Ascl2 locus in C...

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Detalles Bibliográficos
Autores principales: Shang, Yangyang, Jiang, Tao, Ran, Lijian, Hu, Wenjing, Wu, Yun, Ye, Jun, Peng, Zhihong, Chen, Lei, Wang, Rongquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251787/
https://www.ncbi.nlm.nih.gov/pubmed/35660018
http://dx.doi.org/10.1016/j.jbc.2022.102095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251787/
https://www.ncbi.nlm.nih.gov/pubmed/35660018
http://dx.doi.org/10.1016/j.jbc.2022.102095

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