Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the degradation of the low-density lipoprotein receptor. PCSK9 also targets proteins involved in lipid metabolism (very low–density lipoprotein receptor), immunity (major histocompatibility complex I), and viral infection (cluster...

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Detalles Bibliográficos
Autores principales: Saitoski, Kevin, Ryaboshapkina, Maria, Hamza, Ghaith M., Jarnuczak, Andrew F., Berthault, Claire, Carlotti, Françoise, Armanet, Mathieu, Sengupta, Kaushik, Underwood, Christina Rye, Andersson, Shalini, Guillas, Isabelle, Le Goff, Wilfried, Scharfmann, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251788/
https://www.ncbi.nlm.nih.gov/pubmed/35660019
http://dx.doi.org/10.1016/j.jbc.2022.102096

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