Cargando…

SIK2 promotes ovarian cancer cell motility and metastasis by phosphorylating MYLK

Salt‐inducible kinase 2 (SIK2; also known as serine/threonine‐protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration and metastasis in ovarian cancer have not been fully d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Xiu, Yu, Xuejiao, Wang, Juan, Bian, Shimin, Li, Qiutong, Fu, Fengqing, Zou, Xinwei, Zhang, Lin, Bast, Robert C., Lu, Zhen, Guo, Lingchuan, Chen, Youguo, Zhou, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251837/ https://www.ncbi.nlm.nih.gov/pubmed/35278271 http://dx.doi.org/10.1002/1878-0261.13208

Ejemplares similares

MTHFD2 promotes ovarian cancer growth and metastasis via activation of the STAT3 signaling pathway
por: Li, Qiutong, et al.
Publicado: (2021)

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations
por: Tougas, Carson L., et al.
Publicado: (2019)

SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers
por: Lu, Zhen, et al.
Publicado: (2022)

MicroRNA-708 Suppresses Cell Proliferation and Enhances Chemosensitivity of Cervical Cancer Cells to cDDP by Negatively Targeting Timeless
por: Zou, Xinwei, et al.
Publicado: (2020)

Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
por: Park, Minjeong, et al.
Publicado: (2020)

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages
por: Darling, Nicola J., et al.
Publicado: (2017)

Identification of MYLK3 mutations in familial dilated cardiomyopathy
por: Tobita, Takashige, et al.
Publicado: (2017)

MYLK and CALD1 as molecular targets in bladder cancer
por: Jin, Hui, et al.
Publicado: (2023)

SIKs control osteocyte responses to parathyroid hormone
por: Wein, Marc N., et al.
Publicado: (2016)

BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1
por: Wang, Qiang, et al.
Publicado: (2022)

An allosteric regulation mechanism of Arabidopsis Serine/Threonine kinase 1 (SIK1) through phosphorylation
por: Mu, Junxi, et al.
Publicado: (2021)

ROCK2 and MYLK variants and high-altitude pulmonary edema
por: Sikri, Gaurav, et al.
Publicado: (2016)

Corrigendum: SIKs control osteocyte responses to parathyroid hormone
por: Wein, Marc N., et al.
Publicado: (2017)

LKB1 inhibits proliferation, metastasis and angiogenesis of thyroid cancer by upregulating SIK1
por: Kou, Bo, et al.
Publicado: (2022)

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser(358) in adipocytes
por: Henriksson, Emma, et al.
Publicado: (2012)

SIK1 suppresses colorectal cancer metastasis and chemoresistance via the TGF-β signaling pathway
por: Gao, Yuan, et al.
Publicado: (2023)

Nuts and bolts of the salt-inducible kinases (SIKs)
por: Darling, Nicola J., et al.
Publicado: (2021)

Circular RNA MYLK promotes tumour growth and metastasis via modulating miR‐513a‐5p/VEGFC signalling in renal cell carcinoma
por: Li, Jianfa, et al.
Publicado: (2020)

Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study
por: Phelps, David L, et al.
Publicado: (2017)

The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model
por: Yu, Kewei, et al.
Publicado: (2023)

Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice
por: Uebi, Tatsuya, et al.
Publicado: (2012)

A phosphorylation-deficient mutant of Sik3, a homolog of Sleepy, alters circadian sleep regulation by PDF neurons in Drosophila
por: Kobayashi, Riho, et al.
Publicado: (2023)

A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description
por: Hannuksela, Matias, et al.
Publicado: (2016)

MYLK Mutations: Aortic Disease Presentation, Pregnancy Risk, and Characterization of Pathogenic Missense Variants
por: Wallace, Stephanie E., et al.
Publicado: (2018)

Role of SIK1 in the transition of acute kidney injury into chronic kidney disease
por: Hu, Jinxiu, et al.
Publicado: (2021)

The protein kinase SIK downregulates the polarity protein Par3
por: Vanlandewijck, Michael, et al.
Publicado: (2017)

Hypermethylated FAM5C and MYLK in Serum as Diagnosis and Pre-Warning Markers for Gastric Cancer
por: Chen, Lu, et al.
Publicado: (2012)

A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure
por: Wang, Ting, et al.
Publicado: (2015)

MYLK and PTGS1 Genetic Variations Associated with Osteoporosis and Benign Breast Tumors in Korean Women
por: Cho, Hye-Won, et al.
Publicado: (2021)

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock
por: Jagannath, Aarti, et al.
Publicado: (2013)

Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis
por: Lombardi, Maria Stella, et al.
Publicado: (2017)

The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
por: Sun, Zicheng, et al.
Publicado: (2020)

The Small-Molecule Inhibitor MRIA9 Reveals Novel Insights into the Cell Cycle Roles of SIK2 in Ovarian Cancer Cells
por: Raab, Monika, et al.
Publicado: (2021)

Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network
por: Jin, Yangqiu, et al.
Publicado: (2022)

Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions
por: Wang, Ting, et al.
Publicado: (2018)

Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats
por: Song, DaoFei, et al.
Publicado: (2019)

Got Mylk? The Emerging Role of Australian Plant-Based Milk Alternatives as A Cow’s Milk Substitute
por: Zhang, Yianna Y., et al.
Publicado: (2020)

MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma
por: Yang, Mengkai, et al.
Publicado: (2021)

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis
por: Foroumadi, Roham, et al.
Publicado: (2022)

SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300
por: Zhang, Zhen-Ning, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ilskt2egt0hg4do8fbbfb4tbnd