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Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females

Hepcidin is a liver‐derived hormone that regulates iron metabolism. Recent studies suggest that an energy‐deficient diet or low carbohydrate (CHO) availability may increase hepcidin in the absence of inflammation. The purpose of the present study was to examine the impact of either an energy‐deficie...

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Autores principales: Hayashi, Nanako, Ishibashi, Aya, Iwata, Ayame, Yatsutani, Haruka, Badenhorst, Claire, Goto, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251860/
https://www.ncbi.nlm.nih.gov/pubmed/35785528
http://dx.doi.org/10.14814/phy2.15351
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author Hayashi, Nanako
Ishibashi, Aya
Iwata, Ayame
Yatsutani, Haruka
Badenhorst, Claire
Goto, Kazushige
author_facet Hayashi, Nanako
Ishibashi, Aya
Iwata, Ayame
Yatsutani, Haruka
Badenhorst, Claire
Goto, Kazushige
author_sort Hayashi, Nanako
collection PubMed
description Hepcidin is a liver‐derived hormone that regulates iron metabolism. Recent studies suggest that an energy‐deficient diet or low carbohydrate (CHO) availability may increase hepcidin in the absence of inflammation. The purpose of the present study was to examine the impact of either an energy‐deficient diet or an ED diet with low CHO intake during three consecutive days on hepcidin responses, hematological variables, and energy metabolism in young Japanese women. Twenty‐two young females were divided into two different groups, either an energy‐deficient with low CHO intake group (ED + LCHO; 2.0 ± 0.3 g/kg/day CHO, 39%CHO, 1123 kcal/day) or an energy deficient with moderate CHO intake group (ED; 3.4 ± 0.3 g/kg/day CHO, 63%CHO, 1162 kcal/day). During the three consecutive days of the dietary intervention program, participants consumed only the prescribed diet and maintained their habitual physical activity levels. Body composition, substrate oxidation, iron metabolism, and inflammation were evaluated pre‐ and post‐intervention. Serum iron and ferritin levels were significantly elevated following the intervention (p < 0.001, p = 0.003, respectively). Plasma interleukin‐6 (IL‐6) levels did not change following the intervention. Serum hepcidin levels significantly increased after the intervention (p = 0.002). Relative change in hepcidin levels was significantly higher in the ED + LCHO (264.3 ± 87.2%) than in the ED group (68.9 ± 22.1%, p = 0.048). Three consecutive days of an energy‐deficient diet increased fasting hepcidin levels. Moreover, elevated hepcidin levels were further augmented when an energy‐deficient diet was combined with a lower CHO intake.
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spelling pubmed-92518602022-07-08 Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females Hayashi, Nanako Ishibashi, Aya Iwata, Ayame Yatsutani, Haruka Badenhorst, Claire Goto, Kazushige Physiol Rep Original Articles Hepcidin is a liver‐derived hormone that regulates iron metabolism. Recent studies suggest that an energy‐deficient diet or low carbohydrate (CHO) availability may increase hepcidin in the absence of inflammation. The purpose of the present study was to examine the impact of either an energy‐deficient diet or an ED diet with low CHO intake during three consecutive days on hepcidin responses, hematological variables, and energy metabolism in young Japanese women. Twenty‐two young females were divided into two different groups, either an energy‐deficient with low CHO intake group (ED + LCHO; 2.0 ± 0.3 g/kg/day CHO, 39%CHO, 1123 kcal/day) or an energy deficient with moderate CHO intake group (ED; 3.4 ± 0.3 g/kg/day CHO, 63%CHO, 1162 kcal/day). During the three consecutive days of the dietary intervention program, participants consumed only the prescribed diet and maintained their habitual physical activity levels. Body composition, substrate oxidation, iron metabolism, and inflammation were evaluated pre‐ and post‐intervention. Serum iron and ferritin levels were significantly elevated following the intervention (p < 0.001, p = 0.003, respectively). Plasma interleukin‐6 (IL‐6) levels did not change following the intervention. Serum hepcidin levels significantly increased after the intervention (p = 0.002). Relative change in hepcidin levels was significantly higher in the ED + LCHO (264.3 ± 87.2%) than in the ED group (68.9 ± 22.1%, p = 0.048). Three consecutive days of an energy‐deficient diet increased fasting hepcidin levels. Moreover, elevated hepcidin levels were further augmented when an energy‐deficient diet was combined with a lower CHO intake. John Wiley and Sons Inc. 2022-07-03 /pmc/articles/PMC9251860/ /pubmed/35785528 http://dx.doi.org/10.14814/phy2.15351 Text en © 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Hayashi, Nanako
Ishibashi, Aya
Iwata, Ayame
Yatsutani, Haruka
Badenhorst, Claire
Goto, Kazushige
Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title_full Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title_fullStr Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title_full_unstemmed Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title_short Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
title_sort influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251860/
https://www.ncbi.nlm.nih.gov/pubmed/35785528
http://dx.doi.org/10.14814/phy2.15351
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