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Administration of Phosphonate Inhibitors of Dehydrogenases of 2-Oxoglutarate and 2-Oxoadipate to Rats Elicits Target-Specific Metabolic and Physiological Responses

In vitro and in cell cultures, succinyl phosphonate (SP) and adipoyl phosphonate (AP) selectively target dehydrogenases of 2-oxoglutarate (OGDH, encoded by OGDH/OGDHL) and 2-oxoadipate (OADH, encoded by DHTKD1), respectively. To assess the selectivity in animals, the effects of SP, AP, and their mem...

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Detalles Bibliográficos
Autores principales:	Bunik, Victoria I., Artiukhov, Artem V., Kazantsev, Alexey V., Aleshin, Vasily A., Boyko, Alexandra I., Ksenofontov, Alexander L., Lukashev, Nikolay V., Graf, Anastasia V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252169/ https://www.ncbi.nlm.nih.gov/pubmed/35795216 http://dx.doi.org/10.3389/fchem.2022.892284

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