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Minimal Change Disease in an Adult: A Case Report

Minimal change disease is an important cause of nephrotic syndrome in children, however, few cases are seen among adults. There is very little literature regarding the occurrence of minimal change disease in adults. We reported a case of a 63-year-old male who presented with the complaint of swellin...

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Autores principales: Neupane, Shashank, Pudasaini, Prasamsa, Sharma, Anupam, Sharma, Shriya, Adhikari, Aakriti, Roka, Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the Nepal Medical Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252239/
https://www.ncbi.nlm.nih.gov/pubmed/35633209
http://dx.doi.org/10.31729/jnma.7433
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author Neupane, Shashank
Pudasaini, Prasamsa
Sharma, Anupam
Sharma, Shriya
Adhikari, Aakriti
Roka, Kumar
author_facet Neupane, Shashank
Pudasaini, Prasamsa
Sharma, Anupam
Sharma, Shriya
Adhikari, Aakriti
Roka, Kumar
author_sort Neupane, Shashank
collection PubMed
description Minimal change disease is an important cause of nephrotic syndrome in children, however, few cases are seen among adults. There is very little literature regarding the occurrence of minimal change disease in adults. We reported a case of a 63-year-old male who presented with the complaint of swelling around the eyes mostly during the morning for 18 days and frothing of urine for 7 days. On examination, the patient was ill-looking and had edema around the eyes and over the ankles. After preliminary investigations, renal biopsy was performed and electron microscopy revealed diffuse effacement of foot processes of visceral epithelial cells suggesting minimal change disease (podocytopathy). The patient has been treated with tablet prednisolone 60 mg per oral once daily, tablet ramipril 2.5 mg per oral once daily, and tablet torsemide 20 mg per oral twice daily. Hence, minimal change disease should also be considered as a differential diagnosis in adults presenting with the features of nephrotic syndrome.
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spelling pubmed-92522392022-07-12 Minimal Change Disease in an Adult: A Case Report Neupane, Shashank Pudasaini, Prasamsa Sharma, Anupam Sharma, Shriya Adhikari, Aakriti Roka, Kumar JNMA J Nepal Med Assoc Case Report Minimal change disease is an important cause of nephrotic syndrome in children, however, few cases are seen among adults. There is very little literature regarding the occurrence of minimal change disease in adults. We reported a case of a 63-year-old male who presented with the complaint of swelling around the eyes mostly during the morning for 18 days and frothing of urine for 7 days. On examination, the patient was ill-looking and had edema around the eyes and over the ankles. After preliminary investigations, renal biopsy was performed and electron microscopy revealed diffuse effacement of foot processes of visceral epithelial cells suggesting minimal change disease (podocytopathy). The patient has been treated with tablet prednisolone 60 mg per oral once daily, tablet ramipril 2.5 mg per oral once daily, and tablet torsemide 20 mg per oral twice daily. Hence, minimal change disease should also be considered as a differential diagnosis in adults presenting with the features of nephrotic syndrome. Journal of the Nepal Medical Association 2022-04 2022-04-30 /pmc/articles/PMC9252239/ /pubmed/35633209 http://dx.doi.org/10.31729/jnma.7433 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Neupane, Shashank
Pudasaini, Prasamsa
Sharma, Anupam
Sharma, Shriya
Adhikari, Aakriti
Roka, Kumar
Minimal Change Disease in an Adult: A Case Report
title Minimal Change Disease in an Adult: A Case Report
title_full Minimal Change Disease in an Adult: A Case Report
title_fullStr Minimal Change Disease in an Adult: A Case Report
title_full_unstemmed Minimal Change Disease in an Adult: A Case Report
title_short Minimal Change Disease in an Adult: A Case Report
title_sort minimal change disease in an adult: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252239/
https://www.ncbi.nlm.nih.gov/pubmed/35633209
http://dx.doi.org/10.31729/jnma.7433
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