Cargando…

General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala

Three studies provide evidence that the central nucleus of the amygdala, a structure with a well-established role in conditioned freezing, is also required for conditioned facilitation of instrumental avoidance in rats. First, the immediate early gene c-Fos was measured following the presentation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ian T., Farb, Claudia, Hou, Mian, Prasad, Sunanda, Talley, Elyse, Cook, Savannah, Campese, Vincent D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252428/
https://www.ncbi.nlm.nih.gov/pubmed/35795380
http://dx.doi.org/10.3389/fnbeh.2022.879168
_version_ 1784740262514262016
author Kim, Ian T.
Farb, Claudia
Hou, Mian
Prasad, Sunanda
Talley, Elyse
Cook, Savannah
Campese, Vincent D.
author_facet Kim, Ian T.
Farb, Claudia
Hou, Mian
Prasad, Sunanda
Talley, Elyse
Cook, Savannah
Campese, Vincent D.
author_sort Kim, Ian T.
collection PubMed
description Three studies provide evidence that the central nucleus of the amygdala, a structure with a well-established role in conditioned freezing, is also required for conditioned facilitation of instrumental avoidance in rats. First, the immediate early gene c-Fos was measured following the presentation of a previously shock-paired tone in subjects trained either on an unsignaled avoidance task or not (in addition to tone only presentations in naïve controls). Significantly elevated expression of c-Fos was found in both the avoidance trained and Pavlovian trained conditions relative to naïve controls (but with no difference between the two trained conditions). In a subsequent study, intracranial infusions of muscimol into the central amygdala significantly attenuated the facilitation of shock-avoidance by a shock-paired Pavlovian cue relative to pre-operative responding. The final study used a virogenetic approach to inhibit the central amygdala prior to testing. This treatment eliminated the transfer of motivational control over shock-avoidance by both a shock-paired Pavlovian stimulus, as well as a cue paired with a perceptually distinct aversive event (i.e., klaxon). These findings provide compelling support for a role of central amygdala in producing aversive Pavlovian-instrumental transfer.
format Online
Article
Text
id pubmed-9252428
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92524282022-07-05 General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala Kim, Ian T. Farb, Claudia Hou, Mian Prasad, Sunanda Talley, Elyse Cook, Savannah Campese, Vincent D. Front Behav Neurosci Behavioral Neuroscience Three studies provide evidence that the central nucleus of the amygdala, a structure with a well-established role in conditioned freezing, is also required for conditioned facilitation of instrumental avoidance in rats. First, the immediate early gene c-Fos was measured following the presentation of a previously shock-paired tone in subjects trained either on an unsignaled avoidance task or not (in addition to tone only presentations in naïve controls). Significantly elevated expression of c-Fos was found in both the avoidance trained and Pavlovian trained conditions relative to naïve controls (but with no difference between the two trained conditions). In a subsequent study, intracranial infusions of muscimol into the central amygdala significantly attenuated the facilitation of shock-avoidance by a shock-paired Pavlovian cue relative to pre-operative responding. The final study used a virogenetic approach to inhibit the central amygdala prior to testing. This treatment eliminated the transfer of motivational control over shock-avoidance by both a shock-paired Pavlovian stimulus, as well as a cue paired with a perceptually distinct aversive event (i.e., klaxon). These findings provide compelling support for a role of central amygdala in producing aversive Pavlovian-instrumental transfer. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9252428/ /pubmed/35795380 http://dx.doi.org/10.3389/fnbeh.2022.879168 Text en Copyright © 2022 Kim, Farb, Hou, Prasad, Talley, Cook and Campese. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Kim, Ian T.
Farb, Claudia
Hou, Mian
Prasad, Sunanda
Talley, Elyse
Cook, Savannah
Campese, Vincent D.
General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title_full General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title_fullStr General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title_full_unstemmed General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title_short General and Specific Aversive Modulation of Active Avoidance Require Central Amygdala
title_sort general and specific aversive modulation of active avoidance require central amygdala
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252428/
https://www.ncbi.nlm.nih.gov/pubmed/35795380
http://dx.doi.org/10.3389/fnbeh.2022.879168
work_keys_str_mv AT kimiant generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT farbclaudia generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT houmian generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT prasadsunanda generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT talleyelyse generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT cooksavannah generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala
AT campesevincentd generalandspecificaversivemodulationofactiveavoidancerequirecentralamygdala