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Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

In an increasingly aged global population, achieving healthy life expectancy through natural and safe drug interventions is highly desirable. Here we show that total ginsenosides (TGGR), the main active components in the traditional Chinese medicine, ginseng, promote longevity across species. In Dro...

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Autores principales: Zhao, Qiushi, Liu, Ying, Zhang, Siyu, Zhao, Yuchu, Wang, Chenxi, Li, Keqiang, Jin, Zecheng, Qiao, Juhui, Liu, Meichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252430/
https://www.ncbi.nlm.nih.gov/pubmed/35795238
http://dx.doi.org/10.3389/fnagi.2022.870326
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author Zhao, Qiushi
Liu, Ying
Zhang, Siyu
Zhao, Yuchu
Wang, Chenxi
Li, Keqiang
Jin, Zecheng
Qiao, Juhui
Liu, Meichen
author_facet Zhao, Qiushi
Liu, Ying
Zhang, Siyu
Zhao, Yuchu
Wang, Chenxi
Li, Keqiang
Jin, Zecheng
Qiao, Juhui
Liu, Meichen
author_sort Zhao, Qiushi
collection PubMed
description In an increasingly aged global population, achieving healthy life expectancy through natural and safe drug interventions is highly desirable. Here we show that total ginsenosides (TGGR), the main active components in the traditional Chinese medicine, ginseng, promote longevity across species. In Drosophila, an intriguing effect of TGGR on lifespan was the relatively narrow treatment window to elicit long-term benefits. TGGR administration during early adulthood, and especially during midlife, was sufficient to extend lifespan in both sexes. TGGR did not increase lifespan by reducing food intake or reproductive capacity; rather, TGGR increased the fertility of male Drosophila. TGGR augmented healthspan readouts associated with youth and with healthy aging, such as motility, intestinal barrier integrity, and biorhythm homeostasis. TGGR treatment also improved some types of stress resistance in both sexes, including increased tolerance to starvation and oxidation, and shifting “aged” gene expression patterns toward “healthy” patterns seen in the young. Gene expression, pharmacological and genetic epistatic analyses demonstrated that TGGR effects require normal expression of genes involved in insulin, TOR and MAPK signaling. The positive effects of TGGR on both healthspan and lifespan, coupled with its mechanism of action via evolutionarily conserved signaling pathways, demonstrate it to be a promising anti-aging drug.
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spelling pubmed-92524302022-07-05 Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster Zhao, Qiushi Liu, Ying Zhang, Siyu Zhao, Yuchu Wang, Chenxi Li, Keqiang Jin, Zecheng Qiao, Juhui Liu, Meichen Front Aging Neurosci Neuroscience In an increasingly aged global population, achieving healthy life expectancy through natural and safe drug interventions is highly desirable. Here we show that total ginsenosides (TGGR), the main active components in the traditional Chinese medicine, ginseng, promote longevity across species. In Drosophila, an intriguing effect of TGGR on lifespan was the relatively narrow treatment window to elicit long-term benefits. TGGR administration during early adulthood, and especially during midlife, was sufficient to extend lifespan in both sexes. TGGR did not increase lifespan by reducing food intake or reproductive capacity; rather, TGGR increased the fertility of male Drosophila. TGGR augmented healthspan readouts associated with youth and with healthy aging, such as motility, intestinal barrier integrity, and biorhythm homeostasis. TGGR treatment also improved some types of stress resistance in both sexes, including increased tolerance to starvation and oxidation, and shifting “aged” gene expression patterns toward “healthy” patterns seen in the young. Gene expression, pharmacological and genetic epistatic analyses demonstrated that TGGR effects require normal expression of genes involved in insulin, TOR and MAPK signaling. The positive effects of TGGR on both healthspan and lifespan, coupled with its mechanism of action via evolutionarily conserved signaling pathways, demonstrate it to be a promising anti-aging drug. Frontiers Media S.A. 2022-06-17 /pmc/articles/PMC9252430/ /pubmed/35795238 http://dx.doi.org/10.3389/fnagi.2022.870326 Text en Copyright © 2022 Zhao, Liu, Zhang, Zhao, Wang, Li, Jin, Qiao and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhao, Qiushi
Liu, Ying
Zhang, Siyu
Zhao, Yuchu
Wang, Chenxi
Li, Keqiang
Jin, Zecheng
Qiao, Juhui
Liu, Meichen
Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title_full Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title_fullStr Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title_full_unstemmed Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title_short Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster
title_sort studies on the regulation and molecular mechanism of panax ginseng saponins on senescence and related behaviors of drosophila melanogaster
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252430/
https://www.ncbi.nlm.nih.gov/pubmed/35795238
http://dx.doi.org/10.3389/fnagi.2022.870326
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