Cargando…
Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction
Helicobacter pylori (H. pylori) infection is the strongest causative factor of gastric cancer. Growing evidence suggests that the complex crosstalk of H. pylori and the tumor microenvironment (TME) exerts a profound influence on gastric cancer progression. Hence, there is emerging interest to in-dep...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252590/ https://www.ncbi.nlm.nih.gov/pubmed/35795038 http://dx.doi.org/10.3389/fonc.2022.862462 |
_version_ | 1784740298199400448 |
---|---|
author | Li, Zhifang Zhang, Wenqing Bai, Jinyang Li, Jing Li, Hong |
author_facet | Li, Zhifang Zhang, Wenqing Bai, Jinyang Li, Jing Li, Hong |
author_sort | Li, Zhifang |
collection | PubMed |
description | Helicobacter pylori (H. pylori) infection is the strongest causative factor of gastric cancer. Growing evidence suggests that the complex crosstalk of H. pylori and the tumor microenvironment (TME) exerts a profound influence on gastric cancer progression. Hence, there is emerging interest to in-depth comprehension of the mechanisms of interplay between H. pylori and the TME. This review discusses the regulatory mechanisms underlying the crosstalk between H. pylori infection and immune and stromal cells, including tumor-associated macrophages (TAMs), neutrophils, dendritic cells, myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, B and T cells, cancer associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs), within the TME. Such knowledge will deepen the understanding about the roles of H. pylori in the immune evasion mechanism in gastric cancer and contribute to the development of more effective treatment regimens against H. pylori-induced gastric cancer. |
format | Online Article Text |
id | pubmed-9252590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92525902022-07-05 Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction Li, Zhifang Zhang, Wenqing Bai, Jinyang Li, Jing Li, Hong Front Oncol Oncology Helicobacter pylori (H. pylori) infection is the strongest causative factor of gastric cancer. Growing evidence suggests that the complex crosstalk of H. pylori and the tumor microenvironment (TME) exerts a profound influence on gastric cancer progression. Hence, there is emerging interest to in-depth comprehension of the mechanisms of interplay between H. pylori and the TME. This review discusses the regulatory mechanisms underlying the crosstalk between H. pylori infection and immune and stromal cells, including tumor-associated macrophages (TAMs), neutrophils, dendritic cells, myeloid-derived suppressor cells (MDSCs), natural killer (NK) cells, B and T cells, cancer associated fibroblasts (CAFs), and mesenchymal stem cells (MSCs), within the TME. Such knowledge will deepen the understanding about the roles of H. pylori in the immune evasion mechanism in gastric cancer and contribute to the development of more effective treatment regimens against H. pylori-induced gastric cancer. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9252590/ /pubmed/35795038 http://dx.doi.org/10.3389/fonc.2022.862462 Text en Copyright © 2022 Li, Zhang, Bai, Li and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Zhifang Zhang, Wenqing Bai, Jinyang Li, Jing Li, Hong Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title | Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title_full | Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title_fullStr | Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title_full_unstemmed | Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title_short | Emerging Role of Helicobacter pylori in the Immune Evasion Mechanism of Gastric Cancer: An Insight Into Tumor Microenvironment-Pathogen Interaction |
title_sort | emerging role of helicobacter pylori in the immune evasion mechanism of gastric cancer: an insight into tumor microenvironment-pathogen interaction |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252590/ https://www.ncbi.nlm.nih.gov/pubmed/35795038 http://dx.doi.org/10.3389/fonc.2022.862462 |
work_keys_str_mv | AT lizhifang emergingroleofhelicobacterpyloriintheimmuneevasionmechanismofgastriccanceraninsightintotumormicroenvironmentpathogeninteraction AT zhangwenqing emergingroleofhelicobacterpyloriintheimmuneevasionmechanismofgastriccanceraninsightintotumormicroenvironmentpathogeninteraction AT baijinyang emergingroleofhelicobacterpyloriintheimmuneevasionmechanismofgastriccanceraninsightintotumormicroenvironmentpathogeninteraction AT lijing emergingroleofhelicobacterpyloriintheimmuneevasionmechanismofgastriccanceraninsightintotumormicroenvironmentpathogeninteraction AT lihong emergingroleofhelicobacterpyloriintheimmuneevasionmechanismofgastriccanceraninsightintotumormicroenvironmentpathogeninteraction |