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Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals
Given the rising numbers of older people living with dementia, this study focuses on identifying modifiable health-related factors associated with changes in cognitive status. The predictors of 1-year conversion from Preserved Cognitive Health (PCH) and Mild Cognitive Impairment (MCI) in older adult...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252613/ https://www.ncbi.nlm.nih.gov/pubmed/35795233 http://dx.doi.org/10.3389/fnagi.2022.876359 |
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author | Trevisan, Caterina Siviero, Paola Limongi, Federica Noale, Marianna Maggi, Stefania |
author_facet | Trevisan, Caterina Siviero, Paola Limongi, Federica Noale, Marianna Maggi, Stefania |
author_sort | Trevisan, Caterina |
collection | PubMed |
description | Given the rising numbers of older people living with dementia, this study focuses on identifying modifiable health-related factors associated with changes in cognitive status. The predictors of 1-year conversion from Preserved Cognitive Health (PCH) and Mild Cognitive Impairment (MCI) in older adults were evaluated. Two logistic regression models were performed on data from an Italian multicenter population-based study; both included sociodemographic factors, family history of dementia (FHD), risk behaviors, and depressive symptoms. The first model considered also disease clusters, while the second one included diseases' number and biochemical parameters. The sample involved 459 participants (61.4% women, median age 75 years). Of the 80 PCH individuals at baseline, after 1 year 35 (43.8%) were stable, 44 (55.0%) progressed to MCI, none to dementia, and one to unclassified status. Of the 379 MCI participants at baseline, after 1 year 281 (74.1%) remained stable, 38 (10.0%) reverted to PCH, 15 (4.0%) progressed to dementia, and 45 (11.9%) become unclassifiable. Hypertension/bone and joint diseases cluster was the only predictor of PCH progression to MCI; age and depression were associated with MCI progression to dementia; FHD was associated with MCI reversion to PCH. More diseases and fewer white blood cells were associated with MCI progression to dementia; more diseases and lower platelets were associated with the transition from MCI to unclassifiable; higher Na and lower TSH levels were associated with MCI reversion. The treatment or management of some chronic conditions and electrolyte imbalances may help attenuate cognitive deterioration in older adults with no or MCI. |
format | Online Article Text |
id | pubmed-9252613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92526132022-07-05 Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals Trevisan, Caterina Siviero, Paola Limongi, Federica Noale, Marianna Maggi, Stefania Front Aging Neurosci Aging Neuroscience Given the rising numbers of older people living with dementia, this study focuses on identifying modifiable health-related factors associated with changes in cognitive status. The predictors of 1-year conversion from Preserved Cognitive Health (PCH) and Mild Cognitive Impairment (MCI) in older adults were evaluated. Two logistic regression models were performed on data from an Italian multicenter population-based study; both included sociodemographic factors, family history of dementia (FHD), risk behaviors, and depressive symptoms. The first model considered also disease clusters, while the second one included diseases' number and biochemical parameters. The sample involved 459 participants (61.4% women, median age 75 years). Of the 80 PCH individuals at baseline, after 1 year 35 (43.8%) were stable, 44 (55.0%) progressed to MCI, none to dementia, and one to unclassified status. Of the 379 MCI participants at baseline, after 1 year 281 (74.1%) remained stable, 38 (10.0%) reverted to PCH, 15 (4.0%) progressed to dementia, and 45 (11.9%) become unclassifiable. Hypertension/bone and joint diseases cluster was the only predictor of PCH progression to MCI; age and depression were associated with MCI progression to dementia; FHD was associated with MCI reversion to PCH. More diseases and fewer white blood cells were associated with MCI progression to dementia; more diseases and lower platelets were associated with the transition from MCI to unclassifiable; higher Na and lower TSH levels were associated with MCI reversion. The treatment or management of some chronic conditions and electrolyte imbalances may help attenuate cognitive deterioration in older adults with no or MCI. Frontiers Media S.A. 2022-06-20 /pmc/articles/PMC9252613/ /pubmed/35795233 http://dx.doi.org/10.3389/fnagi.2022.876359 Text en Copyright © 2022 Trevisan, Siviero, Limongi, Noale and Maggi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Trevisan, Caterina Siviero, Paola Limongi, Federica Noale, Marianna Maggi, Stefania Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title | Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title_full | Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title_fullStr | Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title_full_unstemmed | Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title_short | Health-Related Predictors of Changes in Cognitive Status in Community-Dwelling Older Individuals |
title_sort | health-related predictors of changes in cognitive status in community-dwelling older individuals |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252613/ https://www.ncbi.nlm.nih.gov/pubmed/35795233 http://dx.doi.org/10.3389/fnagi.2022.876359 |
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