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MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes

Correct identification and effective visualization of interactions in biomolecular structures facilitate understanding of their functions and molecular design. In response to the practical needs of structure-based analysis, we have created a Mapiya web server. The Mapiya integrates four main functio...

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Detalles Bibliográficos
Autores principales: Badaczewska-Dawid, Aleksandra E, Nithin, Chandran, Wroblewski, Karol, Kurcinski, Mateusz, Kmiecik, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252833/
https://www.ncbi.nlm.nih.gov/pubmed/35524560
http://dx.doi.org/10.1093/nar/gkac307
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author Badaczewska-Dawid, Aleksandra E
Nithin, Chandran
Wroblewski, Karol
Kurcinski, Mateusz
Kmiecik, Sebastian
author_facet Badaczewska-Dawid, Aleksandra E
Nithin, Chandran
Wroblewski, Karol
Kurcinski, Mateusz
Kmiecik, Sebastian
author_sort Badaczewska-Dawid, Aleksandra E
collection PubMed
description Correct identification and effective visualization of interactions in biomolecular structures facilitate understanding of their functions and molecular design. In response to the practical needs of structure-based analysis, we have created a Mapiya web server. The Mapiya integrates four main functionalities: (i) generation of contact maps – intramolecular and intermolecular—for proteins, nucleic acids, and their complexes; (ii) characterization of the interactions physicochemical nature, (iii) interactive visualization of biomolecular conformations with automatic zoom on selected contacts using Molstar and (iv) additional sequence- and structure-based analyses performed with third-party software and in-house algorithms combined into an easy-to-use interface. Thus, Mapiya offers a highly customized analysis of the molecular interactions' in various biological systems. The web server is available at: http://mapiya.lcbio.pl/
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spelling pubmed-92528332022-07-05 MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes Badaczewska-Dawid, Aleksandra E Nithin, Chandran Wroblewski, Karol Kurcinski, Mateusz Kmiecik, Sebastian Nucleic Acids Res Web Server Issue Correct identification and effective visualization of interactions in biomolecular structures facilitate understanding of their functions and molecular design. In response to the practical needs of structure-based analysis, we have created a Mapiya web server. The Mapiya integrates four main functionalities: (i) generation of contact maps – intramolecular and intermolecular—for proteins, nucleic acids, and their complexes; (ii) characterization of the interactions physicochemical nature, (iii) interactive visualization of biomolecular conformations with automatic zoom on selected contacts using Molstar and (iv) additional sequence- and structure-based analyses performed with third-party software and in-house algorithms combined into an easy-to-use interface. Thus, Mapiya offers a highly customized analysis of the molecular interactions' in various biological systems. The web server is available at: http://mapiya.lcbio.pl/ Oxford University Press 2022-05-07 /pmc/articles/PMC9252833/ /pubmed/35524560 http://dx.doi.org/10.1093/nar/gkac307 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Web Server Issue
Badaczewska-Dawid, Aleksandra E
Nithin, Chandran
Wroblewski, Karol
Kurcinski, Mateusz
Kmiecik, Sebastian
MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title_full MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title_fullStr MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title_full_unstemmed MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title_short MAPIYA contact map server for identification and visualization of molecular interactions in proteins and biological complexes
title_sort mapiya contact map server for identification and visualization of molecular interactions in proteins and biological complexes
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252833/
https://www.ncbi.nlm.nih.gov/pubmed/35524560
http://dx.doi.org/10.1093/nar/gkac307
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