Cargando…
Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis
BACKGROUND: Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 4...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252850/ https://www.ncbi.nlm.nih.gov/pubmed/35795381 http://dx.doi.org/10.1155/2022/2623199 |
_version_ | 1784740364391809024 |
---|---|
author | Pan, Jia-Jia Liu, Wei-Li Lu, Guo-Tao Ma, Xing-Jie Zheng, Qing-Bin Wei, Guang-Fa Tian, Ge-Yan Meng, Li-Jun |
author_facet | Pan, Jia-Jia Liu, Wei-Li Lu, Guo-Tao Ma, Xing-Jie Zheng, Qing-Bin Wei, Guang-Fa Tian, Ge-Yan Meng, Li-Jun |
author_sort | Pan, Jia-Jia |
collection | PubMed |
description | BACKGROUND: Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods. We retrospectively collected data from patients with preliminary diagnosis of MSAP and SAP from the Affiliated Hospital of Yangzhou University between January 2014 and June 2018. Serum sex hormones were extracted for further assessment within first 48 h following admission. Logistic regression analysis and the receiving operating characteristic (ROC) curve were applied to evaluate the association and correlation between serum sex hormones and AKI. RESULTS: Data from a total of 122 patients with MSAP or SAP were enrolled in this study. There were no differences in the incidence of AKI between males and females. However, comparing with patients without AKI, those with AKI saw higher estradiol level (p ≤ 0.01) and slight higher progesterone level (p = 0.014) but similar testosterone level (p = 0.668). Interestingly, during both the manual selection and the stepwise backward logistic regression analysis, serum estradiol level was independently associated with AKI in patients with MSAP and SAP (OR 4.699, CI 1.783-12.386, and p = 0.002). Additionally, area under the curve of ROC (AUCROC) showed that serum estradiol level was a proper predictor for AKI (area under the curve 0.875). Specifically, the serum estradiol level of 223.15 pg/mL demonstrated a 92.3% sensitive and a 79.3% specificity in predicting AKI of MSAP and SAP patients, respectively. CONCLUSIONS: High baseline serum estradiol level appears to be an independent risk factor for AKI in patients with MSAP and SAP. It also tends to be an appropriate indicator for AKI. |
format | Online Article Text |
id | pubmed-9252850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-92528502022-07-05 Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis Pan, Jia-Jia Liu, Wei-Li Lu, Guo-Tao Ma, Xing-Jie Zheng, Qing-Bin Wei, Guang-Fa Tian, Ge-Yan Meng, Li-Jun Gastroenterol Res Pract Research Article BACKGROUND: Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI in patients with MSAP and SAP. Patients and Methods. We retrospectively collected data from patients with preliminary diagnosis of MSAP and SAP from the Affiliated Hospital of Yangzhou University between January 2014 and June 2018. Serum sex hormones were extracted for further assessment within first 48 h following admission. Logistic regression analysis and the receiving operating characteristic (ROC) curve were applied to evaluate the association and correlation between serum sex hormones and AKI. RESULTS: Data from a total of 122 patients with MSAP or SAP were enrolled in this study. There were no differences in the incidence of AKI between males and females. However, comparing with patients without AKI, those with AKI saw higher estradiol level (p ≤ 0.01) and slight higher progesterone level (p = 0.014) but similar testosterone level (p = 0.668). Interestingly, during both the manual selection and the stepwise backward logistic regression analysis, serum estradiol level was independently associated with AKI in patients with MSAP and SAP (OR 4.699, CI 1.783-12.386, and p = 0.002). Additionally, area under the curve of ROC (AUCROC) showed that serum estradiol level was a proper predictor for AKI (area under the curve 0.875). Specifically, the serum estradiol level of 223.15 pg/mL demonstrated a 92.3% sensitive and a 79.3% specificity in predicting AKI of MSAP and SAP patients, respectively. CONCLUSIONS: High baseline serum estradiol level appears to be an independent risk factor for AKI in patients with MSAP and SAP. It also tends to be an appropriate indicator for AKI. Hindawi 2022-06-25 /pmc/articles/PMC9252850/ /pubmed/35795381 http://dx.doi.org/10.1155/2022/2623199 Text en Copyright © 2022 Jia-Jia Pan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pan, Jia-Jia Liu, Wei-Li Lu, Guo-Tao Ma, Xing-Jie Zheng, Qing-Bin Wei, Guang-Fa Tian, Ge-Yan Meng, Li-Jun Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title | Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title_full | Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title_fullStr | Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title_full_unstemmed | Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title_short | Baseline Serum Estradiol Level Is Associated with Acute Kidney Injury in Patients with Moderately Severe and Severe Acute Pancreatitis |
title_sort | baseline serum estradiol level is associated with acute kidney injury in patients with moderately severe and severe acute pancreatitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252850/ https://www.ncbi.nlm.nih.gov/pubmed/35795381 http://dx.doi.org/10.1155/2022/2623199 |
work_keys_str_mv | AT panjiajia baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT liuweili baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT luguotao baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT maxingjie baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT zhengqingbin baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT weiguangfa baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT tiangeyan baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis AT menglijun baselineserumestradiollevelisassociatedwithacutekidneyinjuryinpatientswithmoderatelysevereandsevereacutepancreatitis |