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Increased expression of RUNX3 inhibits normal human myeloid development

RUNX3 is a transcription factor dysregulated in acute myeloid leukemia (AML). However, its role in normal myeloid development and leukemia is poorly understood. Here we investigate RUNX3 expression in both settings and the impact of its dysregulation on myelopoiesis. We found that RUNX3 mRNA express...

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Detalles Bibliográficos
Autores principales:	Menezes, Ana Catarina, Jones, Rachel, Shrestha, Alina, Nicholson, Rachael, Leckenby, Adam, Azevedo, Aleksandra, Davies, Sara, Baker, Sarah, Gilkes, Amanda F., Darley, Richard L., Tonks, Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252899/ https://www.ncbi.nlm.nih.gov/pubmed/35490198 http://dx.doi.org/10.1038/s41375-022-01577-2

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