Inability to phosphorylate Y88 of p27(Kip1) enforces reduced p27 protein levels and accelerates leukemia progression

The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) regulates cell proliferation. Phosphorylation of tyrosine residue 88 (Y88) converts the inhibitor into an assembly factor and activator of CDKs, since Y88-phosphorylation restores activity to cyclin E,A/CDK2 and enables assembly of active cyclin...

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Detalles Bibliográficos
Autores principales: Jäkel, Heidelinde, Taschler, Martin, Jung, Karin, Weinl, Christina, Pegka, Fragka, Kullmann, Michael Keith, Podmirseg, Silvio Roland, Dutta, Sayantanee, Moser, Markus, Hengst, Ludger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252907/
https://www.ncbi.nlm.nih.gov/pubmed/35597806
http://dx.doi.org/10.1038/s41375-022-01598-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252907/
https://www.ncbi.nlm.nih.gov/pubmed/35597806
http://dx.doi.org/10.1038/s41375-022-01598-x

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