The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia

The scaffold protein NEDD9 is frequently upregulated and hyperphosphorylated in cancers, and is associated with poor clinical outcome. NEDD9 promotes B-cell adhesion, migration and chemotaxis, pivotal processes for malignant development. We show that global or B-cell-specific deletion of Nedd9 in ch...

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Detalles Bibliográficos
Autores principales: Rusyn, Lisa, Reinartz, Sebastian, Nikiforov, Anastasia, Mikhael, Nelly, vom Stein, Alexander, Kohlhas, Viktoria, Bloehdorn, Johannes, Stilgenbauer, Stephan, Lohneis, Philipp, Buettner, Reinhard, Robrecht, Sandra, Fischer, Kirsten, Pallasch, Christian, Hallek, Michael, Nguyen, Phuong-Hien, Seeger-Nukpezah, Tamina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252910/
https://www.ncbi.nlm.nih.gov/pubmed/35523865
http://dx.doi.org/10.1038/s41375-022-01586-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252910/
https://www.ncbi.nlm.nih.gov/pubmed/35523865
http://dx.doi.org/10.1038/s41375-022-01586-1

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