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Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution

The mechanisms underlying T-ALL relapse remain essentially unknown. Multilevel-omics in 38 matched pairs of initial and relapsed T-ALL revealed 18 (47%) type-1 (defined by being derived from the major ancestral clone) and 20 (53%) type-2 relapses (derived from a minor ancestral clone). In both types...

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Detalles Bibliográficos
Autores principales:	Richter-Pechańska, Paulina, Kunz, Joachim B., Rausch, Tobias, Erarslan-Uysal, Büşra, Bornhauser, Beat, Frismantas, Viktoras, Assenov, Yassen, Zimmermann, Martin, Happich, Margit, von Knebel-Doeberitz, Caroline, von Neuhoff, Nils, Köhler, Rolf, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Kirschner-Schwabe, Renate, Eckert, Cornelia, Avigad, Smadar, Pfister, Stefan M., Muckenthaler, Martina U., Bourquin, Jean-Pierre, Korbel, Jan O., Kulozik, Andreas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252914/ https://www.ncbi.nlm.nih.gov/pubmed/35585141 http://dx.doi.org/10.1038/s41375-022-01587-0

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