Cargando…

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

Detalles Bibliográficos
Autores principales: Olson, Michael L., Mause, Erica R. Vander, Radhakrishnan, Sabarinath V., Brody, Joshua D., Rapoport, Aaron P., Welm, Alana L., Atanackovic, Djordje, Luetkens, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252916/
https://www.ncbi.nlm.nih.gov/pubmed/35490197
http://dx.doi.org/10.1038/s41375-022-01585-2
_version_ 1784740381053681664
author Olson, Michael L.
Mause, Erica R. Vander
Radhakrishnan, Sabarinath V.
Brody, Joshua D.
Rapoport, Aaron P.
Welm, Alana L.
Atanackovic, Djordje
Luetkens, Tim
author_facet Olson, Michael L.
Mause, Erica R. Vander
Radhakrishnan, Sabarinath V.
Brody, Joshua D.
Rapoport, Aaron P.
Welm, Alana L.
Atanackovic, Djordje
Luetkens, Tim
author_sort Olson, Michael L.
collection PubMed
description
format Online
Article
Text
id pubmed-9252916
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-92529162022-07-06 Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion Olson, Michael L. Mause, Erica R. Vander Radhakrishnan, Sabarinath V. Brody, Joshua D. Rapoport, Aaron P. Welm, Alana L. Atanackovic, Djordje Luetkens, Tim Leukemia Letter Nature Publishing Group UK 2022-04-30 2022 /pmc/articles/PMC9252916/ /pubmed/35490197 http://dx.doi.org/10.1038/s41375-022-01585-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Letter
Olson, Michael L.
Mause, Erica R. Vander
Radhakrishnan, Sabarinath V.
Brody, Joshua D.
Rapoport, Aaron P.
Welm, Alana L.
Atanackovic, Djordje
Luetkens, Tim
Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title_full Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title_fullStr Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title_full_unstemmed Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title_short Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion
title_sort low-affinity car t cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing car t cell expansion
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9252916/
https://www.ncbi.nlm.nih.gov/pubmed/35490197
http://dx.doi.org/10.1038/s41375-022-01585-2
work_keys_str_mv AT olsonmichaell lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT mauseericarvander lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT radhakrishnansabarinathv lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT brodyjoshuad lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT rapoportaaronp lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT welmalanal lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT atanackovicdjordje lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion
AT luetkenstim lowaffinitycartcellsexhibitreducedtrogocytosispreventingrapidantigenlossandincreasingcartcellexpansion